About 535 miles
Tennessee, alittle south of Nashville.
8 h 18 min (535.1 miles) via I-75 South and I-65 South
665 miles.
Cox, Ohio is halfway between Detroit and Jonesborough
In the shortest route the two largest would be Memphis and Nashville.
It is 448 miles according to Google Maps.
537 miles taking this route:Take I-75 SOUTH from Detroit down to I-71 SOUTH to LOUISVILLE off EXIT 173 in KENTUCKY.Take I-71 SOUTH to I-265 GENE SNYDER FREEWAY - SOUTH off EXIT 9A.Take I-265 around LOUISVILLE on the GENE SNYDER FREEWAY to I-65 SOUTH to NASHVILLE off EXIT 10-B.Take I-65 SOUTH to Nashville.
Yes.
Yes.
Detroit is a city in Michigan.
Mapquest says about 554 miles (about 9 hours driving time).
It is 496 miles (8 hours 17 minutes) between Nashville, Tennessee and Savannah, Georgia.