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What are biosensors?

Updated: 12/15/2022
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A biosensor is an analytical device which converts a biological response into an electrical signal. The term 'biosensor' is often used to cover sensor devices used in order to determine the concentration of substances or other parameters of biological interest even where they do not utilise a biological system directly for example blood oxygen sats measurments taken by light absorbance measuments.

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A biosensor is an analytical device which consists of 1) biologically sensitive element (frequently and enzyme or antibody). 2)a transducer to transform the signal into another form (eg colour change resulting from an enzyme reaction becomes an electrical signal) 3)An output device e.g. screen/printer.

Almost every dipstick test used by doctors and avalible at your chemist's can be considered a simple form of biosensor. Biosensors relying on colour changes are commonly avalible in the UK over the counter as pregnancy tests and cholesterol test strips the analytes being HCG and Total and/or HLD cholesterol depending on manufacturer.

Biosensors offer the potential for point of care testing as they can be portable and easy to use. The most sucessful biosensor to date is the glucose biosensor used be many diabetics to monitor blood glucose levels. The glucose biosensor is an amperometric device relying on the current generated when glucose oxidase reduces FAD to FADH2 and the resulting FADH2 is then oxidised by an electrode held at constant +ve voltage.

The glucose sensor is sucessful as there is a relativly large concentration of glucose in blood plasma, other biologically relevant analytes are not so abundant and amplification of the signal must be achieved. Amplification by carrier systems for electons and membrane bound electron transfer pathways are common research themes.

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