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Activating groups donate electron density either through inductive effects or resonance. They are usually ortho and para directed, which means the subsequent groups added will either be in the 2 or 4 position relative to the functional group.

It is easy to determine if a functional group is activating if it electronegative molecules are single bonded.

Examples: alkyl groups (-CH3), alkoxyl (-OCH3), amino (-NH2), thio (-SH),

The exception to the trend that activating groups = ortho/para are halides. Halides are deactivating groups because of strong electronegativity, but they are also ortho and para.

Molecules that are double bonded like -NO2, HSO4, and halides are deactivating. They are meta directed, adding molecules at the 3 position.

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Q: What are the differences between activating and deactivating groups in electrophillic aromatic substitution?
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