Prothrombin time (PT) measures the activity of coagulation factors in the tissue factor pathway of the coagulation cascade.
Intrinsic pathway of coagulation (measured as PTT in laboratories).
coagulation
Blood coagulation can explain the concept of coagulation. When we have a cut in our skin, the blood loss would be stopped by fibrin clot formation. This is formed by series of pathways formed by blood clotting factors, thrombin and fibrin.
Generally precious metals as Au, Ag, Pt, Pd, Ir.
normal coagulation time= 3 to 8 minutes.
The prothrombin time (PT) test measures how long it takes for blood to clot. This test evaluates the coagulation factors involved in the extrinsic pathway.
PT/PTT and INR
Prothrombin time (PT) and partial thromboplastin time (PTT) tests are used to evaluate the extrinsic coagulation system
Intrinsic pathway of coagulation (measured as PTT in laboratories).
Prothrombin time (PT) and partial thromboplastin time (PTT) are tests that are used to evaluate the extrinsic coagulation system.
Extrinsic
coagulation
As most coagulation factor proteins are produced in the liver, any disease of the liver will have an effect on the levels of coagulation factors, and in turn the patients' ability to form a clot. Therefore it is normal for a patient with liver problems to have a prolonged PT The in vitro test of PT tests for deficiencies of factors I, II, VII & X. If your aPTT was normal, the deficient factor will be VII, as deficiency in others would have had an effect on the aPTT too
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It may mean that the patient has a vitamin K deficiency, a liver disease, or disseminated intravascular coagulation (DIC).
A coagulation cascade is the sequence of biochemical activities, involving clotting factors, that stop bleeding by forming a clot.
Blood coagulation can explain the concept of coagulation. When we have a cut in our skin, the blood loss would be stopped by fibrin clot formation. This is formed by series of pathways formed by blood clotting factors, thrombin and fibrin.