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Dander is dead skin, much like dandruff. It is a fine powder and a major cause of pet Allergies. Senstitive individuals get an immune reaction when they breathe pet dander.

Using the word in idiom form refers to anger. If someone is "getting your dander up," it means they are arousing your anger. This usage is probably unrelated to the other meaning.

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Q: What does the slang word dander mean?
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