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Receptor dimerization is the joining of the receptor proteins. It this step does not take place, then the responder protein will not autophosphorylate. Signal transduction will not occur if the receptor proteins do not join together.
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What membrane receptor undergoes dimerization and autophosphorylation?
tyrosine kinase receptor.
The activation of receptor tyrosine kinases is characterized by what?
Dimerization and phosphorylation
The activation of receptor tyrosine kinases is characterized by?
dimerization and phosphorylation.
What is tyrosine kinase receptor dimerization. Receptor polymorphism and dimerization in drug design?
Tyrosine kinases are present in the membrane as separate entities that are able to dimerize with one another when bound to a ligand...for this reason most TK ligands are multivalent (thus can bind multiple TK's and cluster them with the ability to dimerize for activation...a dimer is simply two TK's together. I suppose I would need a better understanding of what you mean by the latter part of the question. Receptors can be influenced by polymorphisms (different "formula" variations that are expressed in populations which influence binding...Ex replacing a neutral amino acid with a positive affects binding correct?....As far as dimerization as it relates to drug design I must first confess that I'm not a pharmacologist... however my guess would be that they would want to make their products multivalent so that they bind multiple TK's so that they are able to dimerize...(this is merely a guess)
What are important tissue receptor tumor markers?
estrogen receptor, progesterone receptor, interleukin-2 receptor, and epidermal growth factor receptor.
What membrane receptor undergoes dimerization and autophosphorylation?
tyrosine kinase receptor.
The activation of receptor tyrosine kinases is characterized by what?
Dimerization and phosphorylation
The activation of receptor tyrosine kinases is characterized by?
dimerization and phosphorylation.
What is tyrosine kinase receptor dimerization. Receptor polymorphism and dimerization in drug design?
Tyrosine kinases are present in the membrane as separate entities that are able to dimerize with one another when bound to a ligand...for this reason most TK ligands are multivalent (thus can bind multiple TK's and cluster them with the ability to dimerize for activation...a dimer is simply two TK's together. I suppose I would need a better understanding of what you mean by the latter part of the question. Receptors can be influenced by polymorphisms (different "formula" variations that are expressed in populations which influence binding...Ex replacing a neutral amino acid with a positive affects binding correct?....As far as dimerization as it relates to drug design I must first confess that I'm not a pharmacologist... however my guess would be that they would want to make their products multivalent so that they bind multiple TK's so that they are able to dimerize...(this is merely a guess)
Compare two ways that the binding of a signal molecule to a receptor protein causes a change in activity the receiving cell?
1. Insulin binding to insulin receptor tyrosine kinase on hepatocyte: increased glucose uptake, increased glycogen and fatty acid production and decreased catabolism in general (decreased gluconeogenesis, lipolysis, and proteolysis). Insulin binding causes receptor dimerization and self-phosphorylation. Phosphorylated receptor recruits scaffold proteins and downstream target proteins and phosphorylate them. Phosphorylated target proteins serve as kinases and activate or deactivate other proteins by phosphorylation, effecting appropriate effects. 2. Erythropoietin binding to EPO cytokine receptor on Common Myeloid Progenitor cell: eventual differentiation into erythrocyte. Cytokine receptor induces the Jak/STAT pathway resulting in altered gene expression by transcription factors, drastically changing the function and morphology of the cell.
What are important tissue receptor tumor markers?
estrogen receptor, progesterone receptor, interleukin-2 receptor, and epidermal growth factor receptor.
Which receives signals a fluid mosaic model or a receptor?
a receptor
What is serpentine receptor?
A serpentine receptor is a receptor in the cell membrane that plays a role in signal transduction.
How dimerization takes place?
when the two strands or adopters are cutted with same restriction enzyme and they are complementary to each other, they attached and recircularized.
What binds to a signal molecule enabling the cell to respond to the signal molecule?
receptor proteins bind to signal molecules
Is CD4 an adhesion molecule?
The glycoprotein CD4 is a co-receptor. A co-receptor is "a cell surface receptor, which, when bound to its respective ligand, modulates antigen receptor binding or affects cellular activation after antigen-receptor interactions." (MediLexicon)
What is sensorys receptor for smell?
the receptor cells in the olfactory membrane.....
