*Since the only answer to this question would be opinion based, please leave those opinions in the "Discuss Question" section. This does not mean, "Never modify this answer!", rather, keep the answer unspecific to a card(s).*
There is no single "best card". All Yu-Gi-Oh! (YGO!) cards have their strengths and weaknesses that some players find to be the "best" while some will think otherwise.
Also, each a person's criteria for the best YGO! card will differ. Some might define the best as being a card that doesn't need other cards to make the most out of its powerful effects. Another might consider a card that possesses a high amount of synergy with virtually any deck to be the best.
You can research and look up the latest competitive decks featured in tournaments to get an idea of what the "best cards" are. Just keep in mind that cards become popular for different reasons (such as countering another popular card/deck, ease of use, etc.) and does not make a card the "best"; only a means of fulfilling a task.
The answer to this question is based on opinion. However, most people will agree upon "broken" cards as being the "best". These cards are mostly banned from official Duels and Tournaments. The cards that were voted as being the best in a Shonen Jump Magazine survey were Raigeki, Harpie's Feather Duster,Monster Reborn, Premature Burial, and Mirror Force.
In reality, no card is completely unstoppable. Konami attempts to try to balance the game and resorts to banning a card if it is deemed much too powerful against others who do not have the same card in their own Decks.
Exodia is not the strongest card because it is not a single card it is five different cards
the answer is oblisk the tormentor
There is really no such thing as the strongest yu-gi-oh card. However if you are talking about ATK or DEF, it probably be The Creator God of Light, Horakhty.
the 3 egyptain gods uria, hamon and raviel are the best cards to have in a deck
$2.50 + $0.74 is the value of the Yugioh yubel card plus shipping.
a card and a picture
There is no real card such as Hand Control, it was an anime-only card.
yugioh card maker
No, this is an anime rule and does not exist in the card game.
The best card in yugioh is the judegement dragon card.
She doesn't have a Yugioh Card.
$2.50 + $0.74 is the value of the Yugioh yubel card plus shipping.
there's no best yugioh card cuz each card is good in its own special way
a card and a picture
Best place to watch any episodes of Yugioh, Yugioh GX, Yugioh 5D's, and Yugioh Zexal is at the website 4kidstv.com
Cost Down
The best deck for this card would most likely be a beast or an EARTH deck.
There is no real card such as Hand Control, it was an anime-only card.
The Yugioh Card Wave Motion cannon is not a banned card
by bending it or slightly peeking inside
The Elemental Hero Bladedge Yugioh card is worth approximately $1. The price of the Yugioh card will vary depending upon its condition.