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What is the difference between mismatch repair and nucleotide excision repair?
Wiki User
∙ 9y ago
The differences are as follows:
Mismatch repair
DNA polymerase is the enzyme that is responsible for DNA replication. As it copies the the DNA, it can make mistakes. So, when the DNA is copied, mismatch repair proofreads it and makes sure that the nitrogenous bases are correct. If they aren't, then it will take out only the base. However, if the mismatch repair is not functioning, then humans can get some form of cancer.
Excision repair
This mechanism is caused by UV rays or some sort of harmful chemical. Excision repair fixes what portion may have been destroyed by these mutagens. It takes the entire strand and replaces it with a new one. However, if this mechanism doesn't work, then forms of skin cancers arise.
Wiki User
∙ 9y ago
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What is the difference between a base and a nucleotide?
A nucleotide is the sugar (in DNA is a deoxyribose in RNA it's ribose), phosphate group and 1 base. A base pair is the "rung in the ladder" for example in DNA it could be adenine + thymine or guanine + cytosine. In RNA the thymine is replaced by uracil
What is the genetic significance of single nucleotide polymorphism?
Single Nucleotide Polymorphism, often shortened to SNP, pronounced snips, is a DNA sequence which occurs when one nucleotide in the genome differs between species and chromosomes of a human. Almost all single nucleotide polymophisms have two alleles.
Which best describes a difference between transcription and DNA replication-?
Another answer could be that Transcription uses Uracil. This is the answer I got from Apex btw.
Abbreviation for the disease in which one of the enzymes needed to repair sunlight damsaged DNA is missing?
Ultra violet radiation from sunlight causes Pyrimidines in DNA to bind together in a way they aren't supposed to. This binding most often occurs between two thymines creating a thymine dimer. The dimer must be cut out of the DNA strand and replaced in a process called Nucleotide Excision Repair. In the disorder Xeroderma pigmentosum (abbreviated XP) one or more of the excision repair enzymes is missing leading to extreme sensitivity to sunlight and high likelihood of skin cancer.
What did carl rogers view as a cause of most personal problems and unhappiness?
mismatch between an individual's ideal self and real self
What is the primary difference between the excision codes found in the musculoskeletal system subsection and the excision codes found in the integumentary system subsection?
the primary difference is extent
What is the difference between an incision and excision of lymph nodes?
The difference between incision and excision of lymph nodes is very simple. The incision of a lymph node is when the biopsy only takes part of the lymph node during surgery. The excision of the lymph node is when the whole lymph node is removed.
What the difference between total lobectomy and hemithyroidectomy?
Hemithyrodectomy is Lobectomy + isthmus excision
What is the difference between nucleotide deletion and nucleotide insertion?
Here's a sample nucleotide sequence:AATUGCIf there was a nucleotide deletion (let's say the "G" gets deleted), the sequence would become:AATUCIf there was a nucleotide addition/insertion (let's say a "G" was added between "T' and "U"), the sequence would become:AATGUGCThe difference is that a deletion makes the DNA shorter and an insertion makes it longer.
What is the difference between incision and excision?
An incision is the deliberate cut that is performed into the body tissues to gain access to deeper structures whereas excision is the removal of tissues as therapeutic approach.
What is the difference between a variation and a mutation?
mutation is an alteration in the nucleotide sequence of a gene whereas variation is any difference between individuals of a particular species.
What is the primary difference between the ecision codes found in musculoskeletal system and the excision codes found in integumentary system subsection?
The primary difference is extent.
What is the mismatch between the knowledge and skills acquire by the students and the industry needs.?
The disparity between training and the needs of a job is called skills mismatch or education mismatch and is expressed as a lower employability.
What is the mismatch between the knowledge and skills acquired by the students and the needs of industry?
The disparity between training and the needs of a job is called skills mismatch or education mismatch and is expressed as a lower employability.
What is the difference between 5' and 3' end of a DNA molecule?
The 5' end starts with a phosphate as the nucleotide and the 3' end starts with deoxiribose, or the sugar as the nucleotide.
What are modified enzyme?
DNA Modifying EnzymesEukaryotic and prokaryotic cells possess multiple mechanisms to repair DNA and control damage to their genomes. These include base excision repair (BER) and nucleotide excision repair (NER) that excise and replace damaged nucleotide bases and helix-distorting lesions, respectively. Many of the enzymes involved in NER are also active in transcription-coupled repair (TCR) processes. In addition, mismatch repair (MMR) enzymes act to replace mismatched nucleotides and repair insertion/deletion loops. Furthermore, there are two types of double-stranded DNA break repair, homologous recombination (HR) and non-homologous end-joining (NHEJ).Base excision repair proteins correct DNA lesions and ensure that mutations are not propagated. The process of base excision repair is achieved via specific and sequential enzyme activity. Damaged bases are first identified and removed by DNA glycosylases/AP lyases, which break beta-N glycosidic bonds to create an abasic (AP) DNA site. Depending on the initial events of base removal, repair proceeds through either the short patch (1 nucleotide) or long patch (2-10 nucleotides) repair pathways. This involves the AP site being recognized by endonuclease enzymes which nick the damaged DNA, and recruit DNA polymerases to fill the gap in the DNA. Base excision repair is completed by DNA ligase sealing the nick between the two strands.Nucleotide excision is an additional DNA repair mechanism which removes nucleotides that have been damaged by chemicals or ultraviolet radiation. Nucleotide excision generates a short single-stranded DNA gap, which is subsequently used as a template by DNA polymerase. In addition to base and nucleotide excision repair molecules, mismatch repair (MMR) enzymes act to replace mismatched nucleotides and repair insertion/deletion loops. Genotoxic stress can introduce DNA double-strand breaks (DSBs), which are repaired by either homologous recombination or non-homologous end-joining. The Mre11/Rad50/Nbs1 (MRN) complex, along with members of the Rad51 family of proteins, are involved in double-strand break repair during homologous recombination. R&D Systems offers quality DNA enzyme products which include DNA glycosidases, endonucleases, polymerases, ligases, and more.
What are DNA modifying enzymes?
DNA Modifying EnzymesEukaryotic and prokaryotic cells possess multiple mechanisms to repair DNA and control damage to their genomes. These include base excision repair (BER) and nucleotide excision repair (NER) that excise and replace damaged nucleotide bases and helix-distorting lesions, respectively. Many of the enzymes involved in NER are also active in transcription-coupled repair (TCR) processes. In addition, mismatch repair (MMR) enzymes act to replace mismatched nucleotides and repair insertion/deletion loops. Furthermore, there are two types of double-stranded DNA break repair, homologous recombination (HR) and non-homologous end-joining (NHEJ).Base excision repair proteins correct DNA lesions and ensure that mutations are not propagated. The process of base excision repair is achieved via specific and sequential enzyme activity. Damaged bases are first identified and removed by DNA glycosylases/AP lyases, which break beta-N glycosidic bonds to create an abasic (AP) DNA site. Depending on the initial events of base removal, repair proceeds through either the short patch (1 nucleotide) or long patch (2-10 nucleotides) repair pathways. This involves the AP site being recognized by endonuclease enzymes which nick the damaged DNA, and recruit DNA polymerases to fill the gap in the DNA. Base excision repair is completed by DNA ligase sealing the nick between the two strands.Nucleotide excision is an additional DNA repair mechanism which removes nucleotides that have been damaged by chemicals or ultraviolet radiation. Nucleotide excision generates a short single-stranded DNA gap, which is subsequently used as a template by DNA polymerase. In addition to base and nucleotide excision repair molecules, mismatch repair (MMR) enzymes act to replace mismatched nucleotides and repair insertion/deletion loops. Genotoxic stress can introduce DNA double-strand breaks (DSBs), which are repaired by either homologous recombination or non-homologous end-joining. The Mre11/Rad50/Nbs1 (MRN) complex, along with members of the Rad51 family of proteins, are involved in double-strand break repair during homologous recombination. R&D Systems offers quality DNA enzyme products which include DNA glycosidases, endonucleases, polymerases, ligases, and more.
