PLS affects a part of the neuron called the cell body (or soma). Specifically, it is the cell bodies of upper motor neurons that are affected.
Motor neuron diseases like primary lateral sclerosis develop because the nerve cells that normally control the movement of voluntary muscles degenerate and die.
They are the same.
Several diseases attack the motor neurons that have cell bodies located in the anterior horn of the spinal column namely: amyotropic lateral sclerosis, spinal muscular atrophies, primary lateral sclerosis, and Kennedy's disease (see the linked article for more detail).
The symptoms of the disorder become progressively worse, with muscles typically affected in the following order: legs and feet, main part of the body (the trunk), arms and hands, and face.
Amyotrophic lateral sclerosis (ALS), spinal muscular atrophy , poliomyelitis , and primary lateral sclerosis are all examples of motor neuron diseases
a rare disease that causes progressive weakness in voluntary muscles such as in the legs, hands, and tongue. PLS is one of the diseases, along with amyotrophic lateral sclerosis, that are grouped together as motor neuron diseases.
The disease is typically detected in middle age, after age 50.
Treatment of PLS involves the family physician, a neurologist , and others such as physical therapists.
PLS is not fatal, and people with the disorder can usually maintain mobility with the use of canes or other assistance.
ALS is known to affect two to three people per 100,000. Tentative estimates of the occurrence of PLS are on the order of one person in 10 million
No, the association neurons connect other neurons.
The treatment aims to reduce the discomfort and inconvenience of the disease. There is currently no cure for PLS. Medications such as baclofen, diazepam , and gabapentin have shown effectiveness in reducing muscle spasms in many patients with PLS.