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Ras is a GTPase that functions in many growth-factor signaling pathways. In its active form,with GTP bound, it transmits a downstream signal that leads to cell proliferation; in its inactive form, with GDP bound, the signal is not transmitted. Uncontrolled growth of cancer cells will occur when there is an alteration that decreases the rate of hydrolysis of GTP by Ras. If thius rate is decreased, GTP will not be hydrolysed as quickly to GDP, causing there to be more cell proliferation than needed.

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Q: Which alteration of oncogen Ras activity is most likely to contribute to the uncontrolled growth of cancer cells?
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