Sanibel's first-known settlers were the Calusa, a powerful and well-organized Indian tribe who dominated the majority of the land in Southwest Florida more than 2500 years ago. The Calusa were proficient in creating canals and waterways, which allowed them to live primarily on a native seafood diet.
Florida
about 43 miles
about 150 miles
The driving distance from Orlando to Sanibel Island is approximately 220 miles, which would take around 3.5-4 hours by car, depending on traffic and route taken.
The distance from Panama City Beach to Sanibel is 338 Miles.
The Keys are 120 miles long. Sanibel Island to Key West is 311 miles.
Southwest Florida International is approximately 26 miles east of Sanibel.
The distance between Key West in Florida to Sanibel Island in Florida is 132 miles. You would travel in a north west direction to get there.
The closest town to midway between Sanibel Island, Florida and Hilton Head Island, South Carolina is Citra, Florida. The closest large town is Gainesville, Florida but it's a little way off the shortest route.
124 miles
almost three hours
about 150 miles