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Why does alcohol abuse increase tolerance to other drugs such as barbiturates?

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Enzymes of the smooth ER help detoxify drugs and poisons, especially in liver cells. Detoxification usually involves adding hydroxyl groups to drugs, making them more soluble and easier to flush from the body. The sedative phenobarbital and other barbiturates are examples of drugs metabolized in the manner by smooth ER in liver cells. In fact, barbiturates, alcohol, and many other drugs induce the proliferation of the smooth ER and its associated detoxification enzymes. This, in turn, increases tolerance to the drugs, meaning that higher doses are required to achieve a particular affect, such as sedation. Also, because some other the detoxification enzymes have relatively broad action, the proliferation of the smooth ER in response to one drug can increase tolerance to other drugs as well. Barbiturate abuse, for example, may decrease the effectiveness of certain antibiotics and other useful drugs.
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How does drug and alcohol abuse begin?

    Experimentation and denial. Experimentation is normal curiosity. The denial begins when you start to tell yourself, "Hey, this is no big deal! I can handle it."

What is drug alcohol abuse?

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What are the risks for drug and alcohol abuse?

It depends what you constitute as abuse. Some people can use drugs and alcohol with no negative social impact. However, there are some people who have no self control and ruin

What are the causes of drug abuse and alcoholism?

People usually develop drug or alcohol addictions because they are unhappy, and are self-medicating to feel better. This is especially common among people with psychiatric dis

When does Drug and alcohol abuse start?

Certain drug abuses can start right in the doctor office. If a person is prescribed a narcotic such as codeine, they can become addicted very quickly, even if the doctor says

What is drug and alcohol tolerance?

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What are the effects of barbiturates on other drugs?

They may add to the effects of alcohol and other drugs that slow the central nervous system, such as antihistamines, cold medicine, allergy medicine, sleep aids, medicine for