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The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes.

For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia.

In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.

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7y ago
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13y ago

Because, Hemophilia is caused by a recessive allele on the X chromosome. Because it was a Sex disorder, it occurs more often in males than females.

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Q: Why is hemophilia more common in males than in females?
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