Hemophilia

Hemophilia is a rare bleeding disorder characterized by abnormal blood clotting. The most common signs of hemophilia are easy bruising and too much bleeding. People suffering from hemophilia have less or no clotting factor.

1,540 Questions
Genetics
Hemophilia

Which parent do you inherit hemophilia from?

Hemophilia is most often passed down from mother to son. It is possible for hemophilia to be the result of a spontaneous mutation (approximately 1/3 of the known cases are). Hemophilia is due to a mutation on the X chromosome. Females have two X chromosomes whereas males only have one. When a boy is born, he takes one X chromosome from his mother and one Y chromosome from his father. Therefore, he

can inherit hemophilia only from his mother.

Example One:

Mother(Carrier)+Father(Non-Affected)=50% chance of their son

acquiring the disorder and 50% chance of their daughter being a

carrier.

Example Two:

Mother(Non-Affected)+Father(Hemophiliac)=All sons will be

non-affected and all daughters will be carriers.

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Conditions and Diseases
Genetics
Hemophilia

How can Hemophilia Be Detected before Birth?

Amniocentesis is the most common form of testing for hemophilia prior to birth. This involves drawing off fluids that contain some fetal cells through a needle. Those cells can then be tested for the mutation and thus detect hemophilia before birth. It is important to note that this can only be done after the fetus is 13 weeks along or older.

Between weeks 10 and 12, a procedure called chorionic villus sampling can also be preformed. Using this method, a small piece of the placenta is removed and tested.

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Conditions and Diseases
Malaria
Hemophilia

Are people with Hemophilia prevented of getting Malaria?

No, hemophilia does not confer an advantage against malaria. People with sickle-cell anemia do have an immunity, of sorts.

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Conditions and Diseases
Doctors
Hemophilia

How do doctors diagnose hemophilia?

Diagnosis for hemophilia is done by a blood test to determine how long the blood takes to clot and if any of the clotting factors are of low quantity or simply missing entirely from the sample of blood.

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Conditions and Diseases
Hemophilia

Is hemophilia dominant or recessive?

Hemophilia ia a sex linked disorder that is normally recessive. There are many cases however where trait shows "incomplete or shared" dominance. In these cases the females will have lowered percentages of the clotting factor proteins and may for all intents and purposes be considered mild or moderate hemophiliacs themselves.

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Conditions and Diseases
Genetics
Hemophilia

What is hemophilia?

Hemophilia is a condition where the blood does not want to clog up or clot in an open wound or abrasion. The cause is a factor deficiency in the plasma of the blood needed to coagulate the blood for it to clot.

It is sex-linked genetic disorder where females carry the condition and pass it on to their children; males exhibit the condition. At present, there is no cure.

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Conditions and Diseases
Hemophilia

Is Hemophilia hereditary or not?

Yes, hemophilia is hereditary. It is passed from mother to son.

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Hemophilia

What is the age range for hemophilia?

Genetic hemophilia is a life-long chronic condition. A person would have it all of their life, from birth to death.

Acquired hemophilia happens as a result of some other circumstance and is not directly linked to age. A person may get acquired hemophilia from causes such as extensive liver damage or certain medications. Since these conditions normally occur in older populations it generally trends that way but is no way limited to that age set.

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Conditions and Diseases
Genetics
Hemophilia

A woman is a carrier for hemophilia what are the chances for sons with hemophilia if the father does not have hemophilia?

50% Chance of a son having the disorder. 50% Chance of a daughter being a carrier.

555657
Conditions and Diseases
Genetics
Hemophilia

Why is hemophilia more common in males than females?

Because, Hemophilia is caused by a recessive allele on the X chromosome. Because it was a Sex disorder, it occurs more often in males than females.

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Conditions and Diseases
Hemophilia

Is there any cure for hemophilia?

No. The disorder is genetic.

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No. Hemophilia is not curable at this time. However, it is treatable. Using blood products, artificial blood clotting factors and in some cases hormones that induce the production of clotting factors, hemophilia can be treated. Hemophiliacs still require careful medical monitoring, but it is fairly manageable today.

However, scientists are considering gene replacement therapy as a possible option in the future.

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Health
Conditions and Diseases
Britain in WW2
Genetics
Hemophilia

Why is hemophilia is a serious disease?

Hemophilia is a serious disease, because even if the person has a small cut they can bleed to death because they don't have platelets to stop the cut from bleeding.

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Conditions and Diseases
Genetics
Hemophilia

Can the environment worsen Hemophilia?

There are no environmental factors that contribute to or worsen the disorder itself, however it can greatly impact the symptoms. As heat dilates blood vessels the temperature can influence the amount of bleeding that takes place after injury. Many people with hemophilia develop hemoarthritis which is arthritisthat results from bleeding into the joints. As anyone with arthritis can tell you, the climate can make a huge difference in the condition and its impact.

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Queen Victoria
Hemophilia

Does a mother pass on hemophilia to her son?

Hemophilia is passed down from mother to son. It is extremely

rare for a woman to have hemophilia. It is necessary, though, for

a woman to be a carrier of the disorder for her son to acquire this

disorder. Females have two X chromosomes whereas males only

have one. When a boy is born, he takes one X chromosome from

his mother and one Y chromosome from his father. Therefore, he

can only get hemophilia through his mother.

Example One:

Mother(Carrier)+Father(Non-Affected)=50% chance of their son

acquiring the disorder and 50% chance of their daughter being a

carrier.

Example Two:

Mother(Non-Affected)+Father(Hemophiliac)=All sons will be

non-affected and all daughters will be carriers.

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Genetics
Color Blindness
Hemophilia

Why must males inherit color blindness or hemophilia from their mothers?

Hemophilia and color blindness are X-linked traits so that males have only one copy of the gene in question and that is from their mother.

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Conditions and Diseases
Death and Dying
Hemophilia

What are some other names for hemophilia?

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Genetic Engineering
Hemophilia

Why is hemophilia considered genetic?

AnswerHaemophilia IS genetic because it is caused by a mutated gene on the x chromosome.

Sorry To Kinda Change This Answer A Little Bit... But I Had This Question For My Biology Homework, Isn't It A Sex-Linked Disorder? I Checked In My Biology Text Book...

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Conditions and Diseases
Biology
Hemophilia

Who discovered hemophilia?

•Abu al-Qasim al-Zahrawi was the first to describe the disease and Dr. John Conrad Otto provided genetic explanation on the disease.

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Hemophilia

Is hemophilia non disjunction?

No. Hemophilia is the result of any of a number of mutations such as reversals, translations, deletions, etc. These mutations need to have occurred in a very specific segment of the coding found on the X chromosome. The replication of that X chromosome however is unaffected with the exception that the mutation on it is replicated as well.

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Health
Hemophilia

Can someone with hemophilia drink alcohol?

Yes, a person with Hemophilia can drink alcohol, however drinking in excess is not good for anyone. Alcohol itself does not interact with the actual medications taken (Clotting Factor Proteins) for hemophilia. Since alcohol can thin a person's blood, alcohol consumption can make a current bleeding issue worse. If there is no active bleed, alcohol should make little to no difference in that end of the hemophiliac's medical spectrum.

Other complications often found in some older hemophiliacs may include liver disease at which point alcohol definitely creates a larger problem and can speed up liver damage but this is not due to hemophilia itself.

In short, Alcohol in excess is not good for anyone, but hemophiliacs can drink alcohol if they are conscious of their own situation and are responsible about it.

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Hemophilia

Does frame shift mutation affect hemophilia?

Frame shift mutations that occur on the X chromosome and within the potion of code that controls the formation of clotting factors can cause hemophilia. Frame shift mutations are only one of many types of mutations that can cause the disorder. For hemophilia it's not so much the type of mutation but the location of the mutation within the genetic code.

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Conditions and Diseases
Hemophilia

What is the cause of hemophilia?

Classic hemophilia is a genetic defect on the X chromosome (so it's "sex linked"), which caused a Factor VIII deficiency.

This mutation can be inherited, i.e. passed down though a family from one generation to the next, however nearly 1/3 of all genetic cases are due to random mutations that take place at the time of conception.

Since the liver is responsible for the production of the clotting factor proteins, hemophilia can also be acquired and not genetic. These cases, while less common, can be caused by things such as liver damage and specific medications.

Symptoms:

  1. Very easily bruised
  2. Prolonged nosebleeds
  3. Excessive bleeding from biting down on the lips or tongue
  4. Excessive bleeding following a tooth extraction
  5. Excessive bleeding following surgery
  6. Blood in the urine (called hematuria)
  7. Bleeding in the knee, elbows, and other joints (appears as joint swelling that feels warm to the touch and normally causes weakness and stiffening of the joint)
  8. Bleeding in the brain
  9. Cuts seem to bleed longer than normal
  10. Arthritic joints at young age

a recessive allele

Hemophilia is a genetic disorder (you inherit it from your parents) where some proteins that cause your blood to clot do not work. This leads to increased bleeding.

Hemophilia is a hereditary (acquired, in rare cases) condition caused by a VIII (Hemophilia A) or IX (Hemophilia B) clotting factor deficiency. Clotting factors work with platelets to clot blood.

recessive allele for the X chromosome

Hemophilia is a sex-linked allele that is found on the X sex chromosome and can be passed on to the offspring of parents who are either carriers or have the disease themselves. Because hemophilia is found on the X chromosome, males are more likely to get this condition than females are.

Nothing specific. its a genetic disorder and happens mainly to males. its a X chromosome recessive dis order.

The decrease or absence of factor VIII

AIDS is not man made.

Hemophilia is caused by a lack of enough clotting factor (8, 9, or 11).

There are two types of hemophilia. One is hemophilia A, and the cause is missing or low levels of clotting factor VIII (8). About 9 out of 10 people who have hemophilia have type A. The other type is hemophilia B. The cause of this is missing or low levels of clotting factor IX (9).

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Conditions and Diseases
Genetics
Hemophilia

Is hemophilia a mutation?

Mutations in the F8 and F9 genes cause hemophilia. Changes in the F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. The F8 gene provides instructions for making a protein called coagulation factor VIII. A related protein, coagulation factor IX, is produced from the F9 gene. Coagulation factors are proteins that work together in the clotting process. After an injury, blood clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Mutations in the F8 or F9 gene lead to the production of an abnormal version of coagulation factor VIII or coagulation factor IX. The altered protein cannot participate effectively in the blood clotting process and, in some cases, the protein does not work at all. A shortage of either protein prevents clots from forming properly in response to injury. These problems with blood clotting lead to excessive bleeding that can be difficult to control. Some mutations almost completely eliminate the activity of coagulation factor VIII or coagulation factor IX, resulting in severe hemophilia. Other mutations reduce but do not eliminate the activity of one of these proteins, which usually causes mild or moderate hemophilia. The other, rare form of this condition, acquired hemophilia, results when the body makes specialized proteins called autoantibodies that attack and disable coagulation factor VIII. The production of autoantibodies is sometimes associated with pregnancy, immune system disorders, cancer, or allergic reactions to certain drugs. In about half of cases, the cause of acquired hemophilia is unknown. Read more about the F8 and F9 genes. Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation must be present in both copies of the gene to cause the disorder. Males are affected by X-linked recessive disorders much more frequently than females. A striking characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. In X-linked recessive inheritance, a female with one altered copy of the gene in each cell is called a carrier. She can pass on the altered gene to her children, but usually does not experience signs and symptoms of the disorder. In about 10 percent of cases, however, females who carry one altered copy of the F8 or F9 gene will experience mild problems with bleeding. From: http://ghr.nlm.nih.gov/condition=hemophilia

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Conditions and Diseases
Hemophilia

What does hemophilia look like?

Hemophilia is invisible except when the afflicted person is bleeding, then it is visible in terms of prolonged bleeding, beyond the point when a normal person would have stopped bleeding.

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Conditions and Diseases
Hemophilia

How did hemophilia get its name?

Hemo (or Heamo) = Blood

philia = flow

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