heart

Heart Disease CAD Go inside the body to see how heart disease develops.

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heart

A. superior vena cava B. pulmonary artery C. left atrium D. left ventricle E. right ventricle F. inferior vena cava G. right atrium H. aorta (Carlyn Iverson)

1. Anatomy.
   1. The chambered muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system.
   2. A similarly functioning structure in invertebrates.
2. The area that is the approximate location of the heart in the body; the breast.
3. 1. The vital center and source of one's being, emotions, and sensibilities.
   2. The repository of one's deepest and sincerest feelings and beliefs: an appeal from the heart; a subject dear to her heart.
   3. The seat of the intellect or imagination: the worst atrocities the human heart could devise.
4. 1. Emotional constitution, basic disposition, or character: a man after my own heart.
   2. One's prevailing mood or current inclination: We were light of heart.
5. 1. Capacity for sympathy or generosity; compassion: a leader who seems to have no heart.
   2. Love; affection: The child won my heart.
6. 1. Courage; resolution; fortitude: The soldiers lost heart and retreated.
   2. The firmness of will or the callousness required to carry out an unpleasant task or responsibility: hadn't the heart to send them away without food.
7. A person esteemed or admired as lovable, loyal, or courageous: a dear heart.
8. 1. The central or innermost physical part of a place or region: the heart of the financial district. See synonyms at center.
   2. The core of a plant, fruit, or vegetable: hearts of palm.
9. The most important or essential part: get to the heart of the matter.
10. A conventional two-lobed representation of the heart, usually colored red or pink.
11. Games.
    1. A red, heart-shaped figure on certain playing cards.
    2. A playing card with this figure.
    3. hearts (used with a sing. or pl. verb) The suit of cards represented by this figure.
    4. A card game in which the object is either to avoid hearts when taking tricks or to take all the hearts.

To encourage; hearten.

at heart

1. In one's deepest feelings; fundamentally.

1. Learned by rote; memorized word for word.

1. To lift one's spirits; make one happy.

1. With the deepest appreciation; most sincerely.

1. To be extremely frightened or anxious.

1. To be well-intentioned.

1. Completely; entirely.

1. In the seat of one's truest feelings.

1. To fall in love with.

1. Loved by or important to one.

1. To win one's affection or love.

1. To take seriously and be affected or troubled by: Don't take my criticism to heart.

1. To one's entire satisfaction, without limitation.

1. To show one's feelings clearly and openly by one's behavior.

1. With great willingness or pleasure.
2. With the deepest feeling or devotion.

1. In a halfhearted manner.

[Middle English hert, from Old English heorte.]

Throughout human history the rhythmic beat of the heart has quintessentially represented life. Until the advent of the heart-lung machine, the lack of a heart beat, unless reversed within a few minutes, invariably signalled death. The beat of our own heart can be apparent to us in the pulse felt, or seen, at various parts of the body, occasionally heard or — because of an unusual rhythm or ‘skipped’ beat — noticeable in the chest.

The heart is a hollow muscular organ. It acts as the ‘prime mover’ for the circulation of the blood and the maintenance of the blood pressure. A certain volume of blood is delivered with each beat, and a further key aspect is the pressure at which this flow is delivered. Vital functions such as those of lungs and kidneys, or the exchange of components of the blood and tissue fluid at the capillaries, are critically dependent on the pressure achieved within the circulatory system.

Anatomy

The heart comprises a series of blood-filled chambers; the walls are composed virtually entirely of muscle cells of a type unique to the heart (cardiac myocytes). The heart is actually two double pumps acting in series; there are four chambers in all. The right side receives blood returning from the entire body (in the great veins) and pumps it into the pulmonary artery, which supplies only the alveoli (gas exchange sites) in the lungs. The left side receives blood from the lungs and pumps it into the aorta, the largest artery. (The heart is generally illustrated as seen from the front, so ‘left’ and ‘right’ appear mirrored.) The aorta branches to form the arterial tree that supplies blood to the whole body. The heart, appropriately, is itself the first organ supplied with blood from the aorta. The coronary arteries open from the beginning of the aorta and take blood to all parts of the heart tissue. Each side of the heart has an upper chamber, the atrium (plural: ‘atria’), into which the veins drain. They serve as antechambers to the respective ventricles, the thicker-walled chambers that lie below them.

Diagrammatic views of the heart to show the chambers and the direction of blood flow: a) from the front; b) cut away from the front; c) from the back
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Atria and valves The arrangement of one-way valves and the prevailing pressures mainly determine blood flow from vein-to-atrium-to- ventricle during the cyclic activity of the heart beat, but some pumping of blood by the atria into the ventricles also occurs. The valves preventing back-flow from ventricle to atrium are tough, parachute-like structures partly anchored in the connective tissue plate which forms the physical union of the ventricular and atrial portions of the heart. Their free edges are restrained by several papillary muscles. These are slim extensions from the inner wall of the ventricles, each with a tendinous end fused with the valve; acting like parachute cords, they prevent the valve being pushed through into the atrium as its flaps become filled when the ventricle contracts and puts pressure on its contents. The mitral (or bicuspid) valve on the left side has two flaps, and the tricuspid valve on the right has three. The ‘parachutes’ press together forming a complete closure preventing regress of blood into the respective atrium whence it came. Instead, when the pressure has risen sufficiently, blood is directed into the pulmonary artery and the aorta through one-way valves which separate them from, and prevent back-flow into, their respective ventricles (see Figure).

The heart beat

The heart beats between 60 and 220 times per minute in a typical young adult; 40 to 50 million beats per year. The rate alters, often rather obviously, according to one's state of physical and mental activity. This results in pumping over 3 million litres of blood (per year) through the body and an equal volume through the lungs. The pump work done by the heart is equivalent to lifting a 1 kg weight to about twice the height of Mount Everest each day. This level of persistent, rhythmic, and decidedly dynamic activity may provoke a sense of awe, although it is hardly more remarkable than the prosaic activity of every other organ — except in its absolute necessity to keep at it! We will first consider the electrical processes of the heart since, like many muscles, it is triggered into activity (contraction, the heart beat) by an electrical wave. This section is followed by consideration of contraction itself.

Electrical aspects The left and right atria beat virtually simultaneously and then, after a fraction of a second's delay, both ventricles contract. Electrical activity, as in most other muscles, triggers the contraction. This activity arises not from excitatory nerve fibres, but spontaneously within the heart itself from a small clump of pacemaker cells near the point where the vena cava joins the right atrium: the sino-atrial (SA) node. The electrical wave, or action potential, spreads across the heart from cell to cell. This spread is made possible because each heart cell is connected to its immediate neighbours at several contact regions which offer a relatively low resistance to the flow of electrical current. All the muscle cells of the heart are thus electrically linked together. This means that the activity spreads as a wave, its direction determined by the cell-to-cell couplings available. It also means that, as far as we know, every cardiac myocyte is active at some stage during every heart beat. The muscle cells of the atria and ventricles only make electrical contact in one small region, the atrio-ventricular (AV) node at the centre of the heart. Thus, activity follows a predictable, regular path — across the right and left atria, through the AV node, along specialized faster-conducting heart cells (Purkinje fibres) on the internal face of the muscular wall between the two ventricles (interventricular septum), and thence through the substance of both ventricles. Heart cells, like other electrically excitable cells, become inexcitable (refractory) for a brief period after each action potential. Consequently, once the wave has passed right through the ventricles it ceases, since there are no non-refractory cells available to excite. A new wave is spontaneously initiated at the pacemaker region.

Contractile (mechanical) aspects All the heart muscle cells are thus electrically excited and it is this that triggers them to contract. The wave of contraction, therefore, follows the same sequence: atria first, then ventricles. The electrical activity triggers an abrupt rise in the concentration of ‘free’ calcium ions inside the cells — a common feature in signalling contraction in muscle of every type. The calcium ions required are derived in part by influx from the extracellular fluid, in part by release from intracellular stores in the sarcoplasmic reticulum. The influx is through calcium-selective channels in the surface membrane which are opened by the depolarization. The influx itself transiently promotes further influx, and also triggers the release of more calcium from the intracellular store.

In each ventricle, as the muscular walls contract (develop tension and shorten) they press upon the blood they enclose. The pressure rises and the AV valve fills out and closes. At this stage of the cycle, the exit valve into the relevant artery (pulmonary artery or aorta) is also closed because the pressure in the arteries is higher than that in the ventricles. Temporarily, each ventricle is thus a closed chamber, it can neither lose nor gain blood, so pressure rises quickly until it exceeds that in the exit artery; the exit valve is then pushed open and blood is ejected, squirted from the ventricles as their muscular walls continue to shorten. The pressure at which the valve opens is much higher on the left side than on the right side, in accordance with the higher blood pressure in the aorta and its branches than in the pulmonary artery and its branches. The resistance offered by the lungs to blood flow is much less than that by the body generally; thus the pressures required of the right ventricle can be lower, yet achieve the same flow rate. Both ventricles eject the same volume of blood (the stroke volume): in the adult heart, about 70 ml (half a teacup) which is half or less of the volume it contained. As action potential finishes, the intracellular calcium concentration has already started to reduce again: some calcium is being ‘pumped’ back into the store, and some is leaving the cell by an ion exchange process. With the raised calcium concentration signal thereby removed, the force of contraction quickly wanes in the muscle, so ventricular pressure falls. The elasticity of the arteries, which were dilated when blood was ejected into them, now ensures that a higher pressure is sustained in them than in the rapidly relaxing ventricles (the ‘garden hose’ effect, familiar to those who have turned off a hose-pipe supply tap only to see water continue squirting as the elastic pipe collapses). The respective exit valves are thus pushed closed again, preventing reflux into the ventricles. Blood pressure, therefore, falls more slowly in the arteries than in the ventricles. At this stage about 90 ml of blood remains in each ventricle. Pressure continues to fall quickly until it is below that in the atria. Thus, the AV valves are pushed open, allowing blood to flow from the atria into the ventricles ‘topping them up’ with more blood. (Despite the appearance in some published schematic diagrams and ‘cartoon’ sequences, at all stages of the heart beat the chambers are ‘full’ of blood. It is the enclosed volume which changes, depending on the tension and elasticity of the muscular walls and the status of the inlet and outlet valves.)

The return of the ventricle to its ‘resting’ shape between beats is due to its own elasticity. Like a squeezed sponge or hollow rubber ball, this significantly ‘sucks’ blood from the atria, thereby contributing to its own filling. The reduction of this factor in old age or its enhancement by athletic training have a major effect on overall cardiac function. These effects are analogous to problems associated with ‘stiff’ inelastic valves which perhaps more obviously compromise effective flow in and out of the chambers of the heart.

The state when the heart is contracting is termed systole (sis'-toe-lee) ; the relaxed state is termed diastole (di-a'-stoe-lee).

Control of pump function

The cardiac output is the volume of blood pumped per minute by each ventricle — some 5 litres/minute at ‘rest’ — and is simply the product of heart rate and stroke volume. Cardiac output will thus alter if either varies. The stroke volume is in turn influenced by cardiac filling and by the contractility of the cardiac muscle itself — its intrinsic ability to contract (shorten and/or produce tension).

Heart rate The earliest human hunters will have noticed, like later horror film makers, that even when removed from the body, the heart continues to beat for a time. Other organs also continue to live, but their activity is hardly as impressive as that of the heart.

Because all the cells of the heart are electrically connected to their neighbours, the whole behaves as a unit. Most regions are inactive, unless artificially stimulated. The activity of the regions with the property of ‘firing’ spontaneously is conducted to all their inactive neighbours, so they act as pacemakers. The inherent pacemaker firing rate, typically about 100 per minute, is influenced by nerve actions of the autonomic nervous system: sympathetic nerves release noradrenaline which increases rate, and parasympathetic (vagus) nerve fibres release acetylcholine which slows the rate. Heart rate typically varies between 60 per minute (in deep sleep) to approaching 200 per minute (during brief bursts of maximal exercise). The normal ‘resting’ rate while sitting, relaxed, is about 70 per minute, but shows wide variation amongst entirely healthy individuals. (In one university class of 350 twenty-year-old students, the range was 48 to 90 per minute.) One common feature is a marked variation within the breathing cycle: breathing in usually increases the rate. Physical fitness, particularly that associated with endurance rather than muscle strength, is often associated with a low resting rate. Extremes such as the tennis player Bjorn Borg, or the professional cyclist Miguel Indurain, with resting values in the low 30s per minute, are well known. Young children have higher resting rates; whilst still in the womb, a baby will have a rate of 120 to 160 beats per minute; it is often reported that rates above 140 indicates a female baby, but there are more reliable tests!

Cardiac filling ‘Filling’ reflects the flow of blood back into the heart (venous return from the lungs and the body). William Harvey observed that the presence of valves requires that blood in the larger veins can only flow towards the heart, the key to recognizing that blood circulates. Amongst other factors, the extent of muscular activity, breathing movements, and body positions (standing, lying, arms or legs raised) all affect the rate of return of blood to the heart. Cardiac muscle shows the unusual property that, within limits, it contracts more powerfully when starting from stretched lengths, so that the ventricle ‘empties’ more forcibly when it is ‘filled’ more than usual. This is achieved at trivial extra metabolic cost; the efficiency of pumping thus increases as output increases; surely a paradigm for ‘productivity gains’. This property allows the heart to compensate automatically when the volume of blood within it at the start of the beat (the end diastolic volume) is greater than previously, by pumping more forcefully, thus ejecting a larger volume. This feature is termed Starling's ‘Law of the Heart’, after one of its discoverers.

Contractility It is obvious that an intrinsically stronger heart will be able to eject blood more forcefully and more completely. Unlike our voluntary (skeletal) muscles, the ‘strength’ of heart muscle can vary quickly, even from one beat to the next. This is because it is sensitive to chemical influences (especially of adrenaline/noradrenaline) and electrical influences that can rapidly modify the intracellular processes that underlie contraction. Additionally, as with voluntary muscle, the extent of growth and development of the heart muscle will affect the overall strength of the organ; athletes generally have thicker heart walls which match the larger muscles in their thicker limbs. A normal, sudden increase in contractility is associated with the onset of physical activity or even with its anticipation; this is signalled to the heart, along with the increase in heart rate, by activity in the sympathetic nerve fibres which release noradrenaline. The combination of higher rate and stronger, more rapid contraction tends to match cardiac output to the increased ‘demands’ for blood flow to the exercising muscles.

The heart of the matter and the matter of the heart

The control systems which influence the heart rate and strength of beating are the same as those implicated in such apparently diverse processes as blushing, breathing rate, sexual arousal, mental stress, or alertness. These links seem to have been recognized by our forebears in advance of the definitive precision of the discoveries of cardiovascular physiology. Poets report that hearts leap, hearts are strong, hearts are united, hearts are hot, heart strings are plucked, hearts are ‘in the mouth’, hearts become feeble, hearts are chilled, hearts tremble, and hearts are broken. In human history, the nature of the circulation of the blood and the (quite literally) central role of the heart in this system are still recent discoveries, even though they rank with the very earliest of the truly ‘modern’ scientific method. Nevertheless, the heart (with perhaps the eye) is the organ most quoted in literature and song to define the essential qualities of life and even its very presence. The ready perception of the action of the heart, its racing rate when we are excited or surprised, aroused or shocked, the shallow, rapid beat encountered in feverish poor health, the occasional irregularity of beat that can concern us all (often, thankfully, quite unnecessarily), together form the shared ‘heart’ experiences of mankind that writers and poets have ever drawn upon. We are generally blissfully unaware of the other hives of metabolic industry that contribute to our physiology. The liver, the thyroid, the hypothalamus, the pituitary, the spleen, the pancreas, not one of these is dignified with a property recognizable to their owners. It is surely the literal vitality of the heart's rhythmic beating, the recognition of its link to the movements of blood, the necessary identity between this continual activity and life itself (outside an operating theatre) that validates the continuing truth of poetic notions of ‘heart’

— David J. Miller

See cardiovascular system. See also autonomic nervous system; blood pressure; blood circulation; blood vessels; cardiac muscle; heart attack; heart block; heart failure; heart sound.

Usually from ox, lamb, pig, or sheep; a 150-g portion is a rich source of protein, niacin, iron, and vitamins B₁ and B₂, also, unusually for a meat product, a good source of vitamin C; contains about 9 g of fat, of which half is saturated; supplies 270 kcal (1130 kJ).

The heart is an amazing pump. It maintains the circulation of blood by beating approximately 70 times a minute, more than 36 million times each year. The heart is about the size of a clenched fist and lies in the chest cavity between the two lungs. Its walls consist mainly of cardiac muscle. It is divided into a left side and a right side, each of which has two chambers: an atrium and a ventricle. Deoxygenated blood from the veins enters the right atrium and is passed through the tricuspid valve into the right ventricle. This contracts and pumps blood through the pulmonary artery into the lungs. Oxygenated blood returns through the pulmonary vein into the left atrium and then into the left ventricle. This contracts forcefully to pump oxygenated blood to the rest of the body. The unidirectional flow of blood is maintained by heart valves.

The heart is a very active organ, and it needs a good supply of oxygen to keep it alive. Some of the oxygenated blood pumped out of the left ventricle goes directly to the heart through the coronary arteries. These branch out to supply the thick heart muscle with oxygen and nutrients. Disease of these arteries causes a heart attack.

Since heart consists almost entirely of muscle, it tends to be quite tough. In general, the younger the animal, the more tender the heart. Beef heart is the largest of those commonly available, followed by those of calves, lambs and chickens. Choose hearts that are fresh-smelling, plump and red, avoiding those with a brown or gray hue. Refrigerate, loosely wrapped, for no more than a day or two. Before using, remove any excess fat and wash thoroughly. Heart can be braised, stewed or chopped and added to cooked dishes such as stews. Small hearts, such as those from young lambs and pigs, are often stuffed and sautéed or roasted and served one per person. Chicken hearts from a young bird can also be sautéed. See also variety meats.

noun

1. The circulatory organ of the body: Slang ticker. See body/spirit.
2. The seat of a person's innermost emotions and feelings: bosom, breast, soul. Idioms: bottom of one's heart, cockles of one's heart, one's heart of hearts. See feelings.
3. The quality of mind enabling one to face danger or hardship resolutely: braveness, bravery, courage, courageousness, dauntlessness, doughtiness, fearlessness, fortitude, gallantry, gameness, intrepidity, intrepidness, mettle, nerve, pluck, pluckiness, spirit, stoutheartedness, undauntedness, valiance, valiancy, valiantness, valor. Informal spunk, spunkiness. Slang gut (used in plural), gutsiness, moxie. See fear/courage.
4. The most central and material part: core, essence, gist, kernel, marrow, meat, nub, pith, quintessence, root¹, soul, spirit, stuff, substance. Law gravamen. See be.
5. A place of concentrated activity, influence, or importance: center, focus, headquarters, hub, seat. See edge/center.
6. A point of origin from which ideas or influences, for example, originate: bottom, center, core, focus, hub, quick, root¹. See start/end.

Idioms beginning with heart:
heart of the matter
hearty
heart and soul
heart goes out to, one's
heart in one's mouth, have one's
heart in the right place, have one's
heart stands still
heart of gold
heart of stone
heart sinks, one's
heart to heart

See also absence makes the heart grow fonder; after one's own heart; at heart; break someone's heart; by heart; change of heart; cold hands, warm heart; cross my heart; cry one's eyes (heart) out; cut to the quick (heart); do one (one's heart) good; eat one's heart out; find it in one's heart; from the bottom of one's heart; get to the heart of; give someone heart failure; half a heart; harden one's heart; have a heart; have no heart for; heavy heart; in one's heart of hearts; lose heart; lose one's heart to; near to one's heart; not have the heart to; open one's heart; pour out one's heart; set one's heart on; sick at heart; steal someone's heart; steel one's heart against; take heart; take to heart; to one's heart's content; warm heart; warm the cockles of one's heart; wear one's heart on one's sleeve; with all one's heart; young at heart.

Definition: courage
Antonyms: cowardice, fear

n

Definition: essence, central part
Antonyms: edge, exterior, exteriority, outside, periphery, surface

n

Definition: person's emotions
Antonyms: head

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Structure of the human heart. Oxygen-rich blood from the lungs enters the heart through the … (credit: © Merriam-Webster Inc.)

Organ that pumps blood, circulating it to all parts of the body (see circulation). The human heart is a four-chambered double pump with its right and left sides fully separated by a septum and subdivided on both sides into an atrium above and a ventricle below. The right atrium receives venous blood from the superior and inferior venae cavae (see vena cava) and propels it into the pulmonary circulation. The left atrium takes in blood from the pulmonary veins and sends it into the systemic circulation. Electrical signals from a natural pacemaker cause the heart muscle to contract. Valves in the heart keep blood flowing in one direction. Their snapping shut after each contraction causes the sounds heard as the heartbeat. See also cardiovascular system.

For more information on heart, visit Britannica.com.

The center portion of a log, usually referring to heartwood or duramen.

A hollow, four-chambered muscular organ lying in the thoracic cavity between the lungs. Its wall consists mainly of cardiac muscle. The heart is divided by a septum into a right and left side, each of which has two chambers: an atrium and a ventricle. Deoxygenated blood from the veins enters the right atrium and is passed into the right ventricle. This contracts and pumps the blood through the pulmonary artery into the lungs. Oxygenated blood returns through the pulmonary vein into the left atrium and then into the left ventricle. This contracts forcefully to pump the oxygenated blood to the rest of the body. Unidirectional flow of blood is maintained by heart valves.

Heart
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The hollow muscular organ that is the center of the circulatory system. The heart pumps blood throughout the intricate system of blood vessels in the body.

The hollow muscular organ lying on the sternum that serves as a pump controlling the blood flow in two circuits, the pulmonary and the systemic. See also circulatory system.

• artificial h. — a mechanical device that replaces the heart by using pulsating air to pump blood to the body. Successfully placed in calves, sheep and dogs as experimental models for the subsequent use of such methods in humans.
• h. attack — see myocardial infarction.
• h. bones — ossicles in the fibrous skeletal ring which surrounds the aortic orifice of the heart in cattle and occasionally in other species; called also ossa cordis.
• h. conducting system — consists of the sinoatrial node, the atrioventricular node, the atrioventricular bundle and its two crura.
• cyanotic h. malformations — insufficient oxygenated hemoglobin is received in the peripheral capillary beds resulting in blue discoloration of tissues, and an incapacity of the body to maintain a life-sustaining level of activity.
• h. disease — an all-embracing term including those diseases in which there is intrinsic disease of the heart such as uremia, valvular disease, African horse sickness, vitamin E–selenium nutritional deficiency, inherited cardiomyopathies of dogs and cattle, altitude sickness, canine parvovirus infection, and in a number of plant and other poisonings. See also mulberry heart disease.
• h. failure cells — hemosiderin-laden macrophages present in the pulmonary alveoli in cases of congestive heart failure.
• h. malformations — includes ectopia cordis, patent foramen ovale, ventricular septal defects such as Fallot's tetralogy, Eisenmenger complex, patent ductus arteriosus, aortic coarctation, right aortic arch persistence, truncus arteriosus persistence, fibroelastosis, subvalvular aortic stenosis, anomalous origin of carotid arteries, transposition of great vessels, pulmonic stenosis, aortic stenosis.
• h. massage — see cardiac massage.
• h. meridian points — acupuncture points along the heart meridian.
• h. rate — the number of contractions of the cardiac ventricles per unit of time. For normal rates see pulse rate.
• h. score — a concept which sets out that performance in racing horses is related to heart size, now a well-established relationship, and that heart size can be estimated in the living horse by the measurement of the QRS interval.
• h. sounds — see heart sounds, heart murmur.
• h. strain — is an unpopular concept in any medical science but overtrained horses which perform poorly do have a high incidence of abnormal T waves.
• h. valve anomalies — failure of complete development of atrioventricular or semilunar valves results in stenosis or incompetence of the valves and often congestive heart failure.
• h. valve hematoma — congenital, usually multiple lesions on the edges of atrioventricular valves, mostly in calves; disappear spontaneously in most cases.
• h. valve thrombosis — common lesion on the free edges of valves, often the source of widespread emboli; on healing leave scarred, insufficient valves.
• h. valves — flaps of endothelial connective tissue that guard the entrance into and exit from the ventricles and bring about unidirectional blood flow. Include the atrioventricular and semilunar valves, the proper closure of which is essential to maintain circulatory equilibrium, can be diseased and cause heart failure. See also heart murmur, endocarditis, endocardiosis.

n.

An automatic, muscular blood-pump. Figuratively, this useful organ is said to be the esat of emotions and sentiments -- a very pretty fancy which, however, is nothing but a survival of a once universal belief. It is now known that the sentiments and emotions reside in the stomach, being evolved from food by chemical action of the gastric fluid. The exact process by which a beefsteak becomes a feeling -- tender or not, according to the age of the animal from which it was cut; the successive stages of elaboration through which a caviar sandwich is transmuted to a quaint fancy and reappears as a pungent epigram; the marvelous functional methods of converting a hard-boiled egg into religious contrition, or a cream-puff into a sigh of sensibility -- these things have been patiently ascertained by M. Pasteur, and by him expounded with convincing lucidity. (See, also, my monograph, The Essential Identity of the Spiritual Affections and Certain Intestinal Gases Freed in Digestion -- 4to, 687 pp.) In a scientific work entitled, I believe, Delectatio Demonorum (John Camden Hotton, London, 1873) this view of the sentiments receives a striking illustration; and for further light consult Professor Dam's famous treatise on Love as a Product of Alimentary Maceration.

Tutor's tip: The "hart" (grown male deer) has a pulsing "heart" (the organ that pumps blood through the circulatory system) and a "hard" (not soft; firm or tough) head.

Quotes:

"The eyes see what the heart loves. If the heart loves God and is single in this devotion, then the eyes will see God whether others see Him or not." - Warren Wiersbe

"Have thy heart in heaven and thy hands upon the earth. Ascend in piety and descend in charity. For this is the Nature of Light and the way of the children." - Thomas Vaughan

"Doubt obscures the true vision of the heart." - Source Unknown

"Advice from a veteran trapeze performer: Throw your heart over the bars and your body will follow." - Source Unknown

"Use your head and your heart, its not everything but its a start." - Source Unknown

"I like people and I like them to like me, but I wear my heart where God put it -- on the inside." - Source Unknown

See more famous quotes about Heart

The heart is the eternal symbol of love, romance, and the very life force within all of humankind. Getting to the "heart of the matter" suggests that the heart rules the source of truth and love. When one is unfair in a particularly insensitive manner, the person and the act are described as "heartless." Friendship, courage, romantic bonds, and emotional expression are also embodied in this symbol.

This article is about the muscular organ. For the human heart, see Human heart. For the radio network, see The Heart Network. For other uses, see Heart (disambiguation).

This article needs additional citations for verification. Please help improve this article by adding reliable references. Unsourced material may be challenged and removed. (July 2009)

Heart

The heart is a muscular organ found in all vertebrates that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions. The term cardiac (as in cardiology) means "related to the heart" and comes from the Greek καρδιά, kardia, for "heart."

The vertebrate heart is composed of cardiac muscle, an involuntary striated muscle tissue which is found only within this organ. The average human heart, beating at 72 beats per minute, will beat approximately 2.5 billion times during an average lifespan. It weighs on average 250 g to 300 g in females and 300 g to 350 g in males.^[1]

Contents 1 Early development 2 Structure 2.1 In Humans 2.2 In fish 2.3 In double circulatory systems 2.4 The fully-divided heart 3 Functioning 4 History of discoveries 5 Healthy heart 6 See also 7 References 8 External links

Early development

Main article: Heart development

The mammalian heart is derived from embryonic mesoderm germ-layer cells that differentiate after gastrulation into mesothelium, endothelium, and myocardium. Mesothelial pericardium forms the inner lining of the heart. The outer lining of the heart, lymphatic and blood vessels develop from endothelium. Myocardium develops into heart muscle.^[2]

From splanchnopleuric mesoderm tissue, the cardiogenic plate develops cranially and laterally to the neural plate. In the cardiogenic plate, two separate angiogenic cell clusters form on either side of the embryo. Each cell cluster coalesces to form an endocardial tube continuous with a dorsal aorta and a vitteloumbilical vein. As embryonic tissue continues to fold, the two endocardial tubes are pushed into the thoracic cavity, begin to fuse together and are completely fused at approximately 21 days.^[3]

At 21 days after conception, the human heart begins beating at 70 to 80 beats per minute and accelerates linearly for the first month of beating.

The human embryonic heart begins beating around 21 days after conception, or five weeks after the last normal menstrual period (LMP), which is the date normally used to date pregnancy. It is unknown how blood in the human embryo circulates for the first 21 days in the absence of a functioning heart. The human heart begins beating at a rate near the mother’s, about 75-80 beats per minute (BPM).

The embryonic heart rate (EHR) then accelerates approximately 100 BPM during the first month of beating, peaking at 165-185 BPM during the early 7th week, (early 9th week after the LMP). This acceleration is approximately 3.3 BPM per day, or about 10 BPM every three days, an increase of 100 BPM in the first month.^[4] After 9.1 weeks after the LMP, it decelerates to about 152 BPM (+/-25 BPM) during the 15th week after the LMP. After the 15th week the deceleration slows reaching an average rate of about 145 (+/-25 BPM) BPM at term. The regression formula which describes this acceleration before the embryo reaches 25 mm in crown-rump length or 9.2 LMP weeks is: Age in days = EHR(0.3)+6. There is no difference in female and male heart rates before birth.^[5]

Structure

The structure of the heart varies among the different branches of the animal kingdom. (See Circulatory system.) Cephalopods have two "gill hearts" and one "systemic heart". In vertebrates, the heart lies in the anterior part of the body cavity, dorsal to the gut. It is always surrounded by a pericardium, which is usually a distinct structure, but may be continuous with the peritoneum in jawless and cartilaginous fish. Hagfishes, uniquely among vertebrates, also possess a second heart-like structure in the tail.^[6]

In Humans

The heart is enclosed in a double-walled sac called the pericardium. The superficial part of this sac is called the fibrous pericardium. This protects the heart, anchors it surroundings structures and prevents overfilling of the heart with blood. It is located anterior to the vertebral column and posterior to the sternum. The size of the heart is about the size of a fist and has a mass of between 250 grams and 350 grams. The heart is composed of three layers, all rich with blood vessels. The superficial layer called visceral layer, the middle layer called myocardium and the third layer called endocardium. The heart has four chambers, two superior atria and two inferior ventricles. The atria are the receiving chambers and the ventricles are the discharging chambers. The pathway of blood through the heart consists of pulmonary circuit and systemic circuit. Blood flows through the heart in one direction from atria to ventricles and out the great arteries. This is done by four valves, tricuspid atrioventicular valve, mitral atrioventicular valve, aortic semilunar valve and pulmonary semilunar valve.^[7]

In fish

Primitive fish have a four-chambered heart. However, the chambers are arranged sequentially, so that this primitive heart is quite unlike the four-chambered hearts of mammals and birds. The first chamber is the sinus venosus, which collects de-oxygenated blood from the body through the hepatic and cardinal veins. From here, blood flows into the atrium, and then to the powerful muscular ventricle, where the main pumping action takes place. The fourth and final chamber is the conus arteriosus, which contains several valves and sends blood to the ventral aorta. The ventral aorta delivers blood to the gills, where it is oxygenated and flows through the dorsal aorta into the rest of the body. (In tetrapods, the ventral aorta has divided in two; one half forms the ascending aorta, while the other forms the pulmonary artery).^[6]

In the adult fish, the four chambers are not arranged in a straight row, but instead form an S-shape, with the latter two chambers lying above the former two. This relatively simple pattern is found in cartilaginous fish, and in the more primitive ray-finned fish. In teleosts, the conus arteriosus is very small, and can more accurately be described as part of the aorta, rather than of the heart proper. The conus arteriosus is not present in any amniotes, presumably having been absorbed into the ventricles over the course of evolution. Similarly, while the sinus venosus is present as a vestigial structure in some reptiles and birds, it is otherwise absorbed into the right atrium and is no longer distinguishable.^[6]

In double circulatory systems

In amphibians and most reptiles, a double circulatory system is used, but the heart is not completely separated into two pumps. The development of the double system is necessitated by the presence of lungs, which deliver oxygenated blood directly to the heart.

In living amphibians, the atrium is divided into two separate chambers by the presence of a muscular septum, although there is only a single ventricle. The sinus venosus, which remains large in amphibians, but connects only to the right atrium, receives blood from the vena cavae, with the pulmonary vein by-passing it entirely to enter the left atrium.

In the heart of lungfish, the septum extends part-way into the ventricle. This allows for some degree of separation between the de-oxygenated bloodstream destined for the lungs, and the oxygenated stream that is delivered to the rest of the body. The absence of such a division in living amphibian species may be at least partly due to the amount of respiration that occurs through the skin in such species; thus, the blood returned to the heart through the vena cavae is, in fact, already partially oxygenated. As a result, there may be less need for a clear division between the two bloodstreams than in lungfish or other tetrapods. Nonetheless, in at least some species of amphibian, the spongy nature of the ventricle seems to maintain more of a separation between the bloodstreams than appears the case at first glance. Furthermore, the conus arteriosus has lost its original valves, and contains instead a spiral valve that divides it into two parallel parts, thus helping to keep the two bloodstreams separate.^[6]

The heart of most reptiles (except for crocodilians; see below) has a similar structure to that of lungfish, but here, the septum is generally much larger. This divides the ventricle into two halves, but because the septum does not reach the whole length of the heart, there is a considerable gap near the openings to the pulmonary artery and the aorta. In practice, however, in the majority of reptilian species, there appears to be little, if any, mixing between the bloodstreams, so that the aorta receives essentially only oxygenated blood. ^[6]

The fully-divided heart

Human heart removed from a 64-year-old male.

Surface anatomy of the human heart. The heart is demarcated by:
-A point 9 cm to the left of the midsternal line (apex of the heart)
-The seventh right sternocostal articulation
-The upper border of the third right costal cartilage 1 cm from the right sternal line
-The lower border of the second left costal cartilage 2.5 cm from the left lateral sternal line.^[8]

Archosaurs (crocodilians and birds) and mammals show complete separation of the heart into two pumps, for a total of four heart chambers; it is thought that the four-chambered heart of archosaurs evolved independently from that of mammals. In crocodilians, there is a small opening, the foramen of Panizza, at the base of the arterial trunks, and there is some degree of mixing between the blood in each side of the heart. Thus, only in birds and mammals are the two streams of blood - those to the pulmonary and systemic circulations - kept entirely separate by a physical barrier.^[6]

In the human body, the heart is usually situated in the middle of the thorax with the largest part of the heart slightly offset to the left (although sometimes it is on the right, see dextrocardia), underneath the sternum. The heart is usually felt to be on the left side because the left heart (left ventricle) is stronger (it pumps to all body parts). The left lung is smaller than the right lung because the heart occupies more of the left hemithorax. The heart is fed by the coronary circulation and enclosed by a sac known as the pericardium and is surrounded by the lungs. The pericardium comprises two parts: the fibrous pericardium, made of dense fibrous connective tissue; and a double membrane structure (parietal and visceral pericardium) containing a serous fluid to reduce friction during heart contractions. The heart is located in the mediastinum, the central sub-division of the thoracic cavity. The mediastinum also contains other structures, such as the esophagus and trachea, and is flanked on either side by the right and left pulmonary cavities, which house the lungs.^[9]

The apex is the blunt point situated in an inferior (pointing down and left) direction. A stethoscope can be placed directly over the apex so that the beats can be counted. It is located posterior to the 5th intercostal space just medial of the left mid-clavicular line. In normal adults, the mass of the heart is 250-350 g (9-12 oz), or about twice the size of a clenched fist (it is about the size of a clenched fist in children), but extremely diseased hearts can be up to 1000 g (2 lb) in mass due to hypertrophy. It consists of four chambers, the two upper atria and the two lower ventricles.

Functioning

In mammals, the function of the right side of the heart (see right heart) is to collect de-oxygenated blood, in the right atrium, from the body (via superior and inferior vena cavae) and pump it, via the right ventricle, into the lungs (pulmonary circulation) so that carbon dioxide can be dropped off and oxygen picked up (gas exchange). This happens through the passive process of diffusion. The left side (see left heart) collects oxygenated blood from the lungs into the left atrium. From the left atrium the blood moves to the left ventricle which pumps it out to the body (via the aorta). On both sides, the lower ventricles are thicker and stronger than the upper atria. The muscle wall surrounding the left ventricle is thicker than the wall surrounding the right ventricle due to the higher force needed to pump the blood through the systemic circulation.

Starting in the right atrium, the blood flows through the tricuspid valve to the right ventricle. Here it is pumped out the pulmonary semilunar valve and travels through the pulmonary artery to the lungs. From there, blood flows back through the pulmonary vein to the left atrium. It then travels through the mitral valve to the left ventricle, from where it is pumped through the aortic semilunar valve to the aorta. The aorta forks and the blood is divided between major arteries which supply the upper and lower body. The blood travels in the arteries to the smaller arterioles, then finally to the tiny capillaries which feed each cell. The (relatively) deoxygenated blood then travels to the venules, which coalesce into veins, then to the inferior and superior venae cavae and finally back to the right atrium where the process began.

The heart is effectively a syncytium, a meshwork of cardiac muscle cells interconnected by contiguous cytoplasmic bridges. This relates to electrical stimulation of one cell spreading to neighboring cells.

Some cardiac cells are self-excitable, contracting without any signal from the nervous system, even if removed from the heart and placed in culture. Each of these cells has its own intrinsic contraction rhythm. A region of the human heart called the sinoatrial node SA node, or pacemaker, sets the rate and timing at which all cardiac muscle cells contract. The SA node generates electrical impulses, much like those produced by nerve cells. Because cardiac muscle cells are electrically coupled by inter-calated disks between adjacent cells, impulses from the SA node spread rapidly through the walls of the artria, causing both artria to contract in unison. The impulses also pass to another region of specialized cardiac muscle tissue, a relay point called the atrioventricular (AV) node, located in the wall between the right artrium and the right ventricle. Here, the impulses are delayed for about 0.1s before spreading to the walls of the ventricle. The delay ensures that the artria empty completely before the ventricles contract. Specialized muscle fibers called Purkinje fibers then conduct the signals to the apex of the heart along and throughout the ventricular walls. The Purkinje fibres form conducting pathways called bundle branches. The impulses generated during the heart cycle produce electrical currents, which are conducted through body fluids to the skin, where they can be detected by electrodes and recorded as an electrocardiogram (ECG or EKG).^[10]

The SA node is found in all amniotes, but not in more primitive vertebrates. In these animals, the muscles of the heart are relatively continuous, and the sinus venosus coordinates the beat, which passes in a wave through the remaining chambers. Indeed, since the sinus venosus is incorporated into the right atrium in amniotes, it is likely homologous with the SA node. In teleosts, with their vestigial sinus venosus, the main centre of coordination is instead in the atrium. The rate of heartbeat varies enormously between different species, ranging from around 20 beats per minute in codfish to around 600 in hummingbirds.^[6]

Cardiac arrest is the sudden cessation of normal heart rhythm which can include a number of pathologies such as tachycardia, an extremely rapid heart beat which prevents the heart from effectively pumping blood, fibrillation which is an irregular and ineffective heart rhythm, and asystole which is the cessation of heart rhythm entirely.

Cardiac tamponade is a condition in which the fibrous sac surrounding the heart fills with excess fluid or blood, suppressing the heart's ability to beat properly. Tamponade is treated by pericardiocentesis, the gentle insertion of the needle of a syringe into the pericardial sac (avoiding the heart itself) on an angle, usually from just below the sternum, and gently withdrawing the tamponading fluids.

History of discoveries

A human heart with a visible gun shot wound

The valves of the heart were discovered by a physician of the Hippocratean school around the 4th century BC. However, their function was not properly understood then. Because blood pools in the veins after death, arteries look empty. Ancient anatomists assumed they were filled with air and that they were for transport of air.

Philosophers distinguished veins from arteries but thought that the pulse was a property of arteries themselves. Erasistratos observed that arteries that were cut during life bleed. He ascribed the fact to the phenomenon that air escaping from an artery is replaced with blood that entered by very small vessels between veins and arteries. Thus he apparently postulated capillaries but with reversed flow of blood.

The 2nd century AD, Greek physician Galenos (Galen) knew that blood vessels carried blood and identified venous (dark red) and arterial (brighter and thinner) blood, each with distinct and separate functions. Growth and energy were derived from venous blood created in the liver from chyle, while arterial blood gave vitality by containing pneuma (air) and originated in the heart. Blood flowed from both creating organs to all parts of the body where it was consumed and there was no return of blood to the heart or liver. The heart did not pump blood around, the heart's motion sucked blood in during diastole and the blood moved by the pulsation of the arteries themselves.

Galen believed that the arterial blood was created by venous blood passing from the left ventricle to the right by passing through 'pores' in the inter ventricular septum, air passed from the lungs via the pulmonary artery to the left side of the heart. As the arterial blood was created 'sooty' vapors were created and passed to the lungs also via the pulmonary artery to be exhaled.

The first major scientific understanding of the heart was put forth by the medieval Arab polymath Ibn Al-Nafis, regarded as the father of circulatory physiology.^[11] He was the first physician to correctly describe pulmonary circulation,^[12] the capillary^[13] and coronary circulations.^[14] Prior to this, Galen's theory was widely accepted, and improved upon by Avicenna. Al-Nafis rejected the Galen-Avicenna theory and corrected many wrong ideas that were put forth by it, and also adding his new found observations of pulse and circulation to the new theory. His major observations include (as surmised by Dr. Paul Ghalioungui):^[13]

1. "Denying the existence of any pores through the interventricular septum."

2. "The flow of blood from the right ventricle to the lungs where its lighter parts filter into the pulmonary vein to mix with air."

3. "The notion that blood, or spirit from the mixture of blood and air, passes from the lung to the left ventricle, and not in the opposite direction."

4. "The assertion that there are only two ventricles, not three as stated by Avicenna."

5. "The statement that the ventricle takes its nourishment from blood flowing in the vessels that run in its substance (i.e. the coronary vessels) and not, as Avicenna maintained, from blood deposited in the right ventricle."

6. "A premonition of the capillary circulation in his assertion that the pulmonary vein receives what comes out of the pulmonary artery, this being the reason for the existence of perceptible passages between the two."

Ibn Al-Nafis also corrected Galen-Avicenna assertion that heart has a bone structure through his own observations and wrote the following criticism on it:^[15]

"This is not true. There are absolutely no bones beneath the heart as it is positioned right in the middle of the chest cavity where there are no bones at all. Bones are only found at the chest periphery not where the heart is positioned."

For more recent technological developments, see Cardiac surgery.

Healthy heart

Obesity, high blood pressure and high cholesterol can increase the risk of developing heart disease. However, fully half the amount of heart attacks occur in people with normal cholesterol levels. Heart disease is a major cause of death (and the number one cause of death in the Western World).

Of course one must also consider other factors such as lifestyle and overall health (mental and social as well as physical).^{[16][17][18][19]}

See also

• Cardiac cycle
• Heart disease
• Human heart
• Electrocardiogram
• Electrical conduction system of the heart
• Physiology
• Trauma triad of death

References

1. ^ Kumar, Abbas, Fausto: Robbins and Cotran Pathologic Basis of Disease, 7th Ed. p. 556
2. ^ Animal Tissues
3. ^ Main Frame Heart Development>
4. ^ OBGYN.net "Embryonic Heart Rates Compared in Assisted and Non-Assisted Pregnancies"
5. ^ Terry J. DuBose Sex, Heart Rate and Age
6. ^ ^{a b c d e f g} Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 437-442. ISBN 0-03-910284-X. 
7. ^ Marieb, Elaine Nicpon. Human Anatomy & Physiology. 6th ed. Upper Saddle River: Pearson Education, 2003. Print
8. ^ Gray's Anatomy of the Human Body - 6. Surface Markings of the Thorax
9. ^ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey: Prentice Hall. ISBN 0-13-981176-1. OCLC 32308337. 
10. ^ Campbell, Reece-Biology, 7th Ed. p.873,874
11. ^ Chairman's Reflections (2004), "Traditional Medicine Among Gulf Arabs, Part II: Blood-letting", Heart Views 5 (2): 74-85 [80]
12. ^ S. A. Al-Dabbagh (1978). "Ibn Al-Nafis and the pulmonary circulation", The Lancet 1: 1148
13. ^ ^{a b} [1] Dr. Paul Ghalioungui (1982), "The West denies Ibn Al Nafis's contribution to the discovery of the circulation", Symposium on Ibn al-Nafis, Second International Conference on Islamic Medicine: Islamic Medical Organization, Kuwait (cf.) The West denies Ibn Al Nafis's contribution to the discovery of the circulation
14. ^ Husain F. Nagamia (2003), "Ibn al-Nafīs: A Biographical Sketch of the Discoverer of Pulmonary and Coronary Circulation", Journal of the International Society for the History of Islamic Medicine 1: 22–28.
15. ^ Dr. Sulaiman Oataya (1982), "Ibn ul Nafis has dissected the human body", Symposium on Ibn al-Nafis, Second International Conference on Islamic Medicine: Islamic Medical Organization, Kuwait (cf. Ibn ul-Nafis has Dissected the Human Body, Encyclopedia of Islamic World).
16. ^ "Eating for a healthy heart". MedicineWeb. http://www.medicineweb.com/nutrition-/eating-for-a-healthy-heart. Retrieved 2009-03-31. 
17. ^ Division of Vital Statistics; Arialdi M. Miniño, M.P.H., Melonie P. Heron, Ph.D., Sherry L. Murphy, B.S., Kenneth D. Kochanek, M.A. (2007-08-21). "Deaths: Final data for 2004" (PDF). National Vital Statistics Reports (United States: Center for Disease Control) 55 (19): 7. http://www.cdc.gov/nchs/data/nvsr/nvsr55/nvsr55_19.pdf. Retrieved 2007-12-30. 
18. ^ White House News. "American Heart Month, 2007". http://georgewbush-whitehouse.archives.gov/news/releases/2007/02/20070201-2.html. Retrieved 2007-07-16. 
19. ^ National Statistics Press Release 25 May 2006

External links

Look up heart in Wiktionary, the free dictionary.

Wikimedia Commons has media related to: Hearts

• Heart contraction and blood flow (animation)
• Heart Disease
• eMedicine: Surgical anatomy of the heart
• Interactive 3D heart This realistic heart can be rotated, and all its components can be studied from any angle.
• Heart Information

v • d • e Anatomy of torso, cardiovascular system: heart (TA A12.1, GA 5.524) General Surface base · apex · grooves (coronary/atrioventricular, interatrial, anterior interventricula, posterior interventricular) · surfaces (sternocostal, diaphragmatic) · borders (right, left) · Openings of smallest cardiac veins Internal atria (interatrial septum, musculi pectinati, sulcus terminalis) · ventricles (interventricular septum, trabeculae carneae, chordae tendineae, papillary muscle) · valves · cusps · Atrioventricular septum cardiac skeleton (fibrous trigone, fibrous rings) Intervenous tubercle Chambers Right heart (vena cavae, coronary sinus) → right atrium (atrial appendage, fossa ovalis, limbus of fossa ovalis, crista terminalis, valve of inferior vena cava, valve of coronary sinus) → tricuspid valve → right ventricle (conus arteriosus, moderator band/septomarginal trabecula)  → pulmonary valve → (pulmonary artery and pulmonary circulation) Left heart (pulmonary veins) → left atrium (atrial appendage) → mitral valve → left ventricle → aortic valve (aortic sinus) → (aorta and systemic circulation) Layers Endocardium Heart valves Myocardium Conduction system: Cardiac pacemaker · SA node · AV node · bundle of His · Purkinje fibers Pericardial cavity Pericardial sinus Pericardium fibrous pericardium (Sternopericardiac ligaments) · serous pericardium (epicardium/visceral layer) · Fold of the left vena cava heart navs: anat/physio/dev, noncongen/congen/neoplasia, symptoms+signs/eponymous, proc

v • d • e Circulatory system: Arteries and veins (TA A12.2-3, GA 6.543/GA 7.641) Systemic circulation (Heart ) → Aorta → Arteries → Arterioles → Capillaries → Venules → Veins → Vena cava → (Heart) Pulmonary circulation (Heart) → Pulmonary arteries → (Lungs) → Pulmonary vein → (Heart) Blood vessels Endothelium · Tunica intima · Tunica media · Tunica externa Vasa vasorum · Vasa nervorum Rete mirabile · Arteriovenous anastomosis Arteries Nutrient artery Veins Vena comitans · Superficial vein · Deep vein · Emissary veins · Venous plexus vascular navs: anat/physio/dev, noncongen/systemic vasculitis/congen/neoplasia, symptoms+signs/eponymous, proc

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Dansk (Danish)
n. - hjerte, mod, centrum, kerne
v. tr. - opmuntre

idioms:

• (not) have the heart to    (ikke) kunne nænne at
• a heart of gold    et hjerte af guld
• at heart    inderst inde, ligge på sinde, hjertesag, meget om at gøre
• broken heart    knust hjerte, ulykkelig kærlighed
• by heart    udenad
• from the bottom of one's heart    af hele ens hjerte
• from the heart    fra hjertet
• give heart    skænke sit hjerte
• have a heart    have hjerte i livet, vær nu lidt rar, lad os nu være mennesker
• have one's heart in one's mouth    med hjertet oppe i halsen
• have one's heart in the right place    have hjertet på rette sted
• heart and soul    med liv og lyst
• heart attack    hjerteanfald
• heart failure    hjertestop, hjertelammelse
• heart of hearts    inderst inde i hjertet
• heart's desire    hjertens lyst
• lose heart    tabe hjerte
• open one's heart    åbne sit hjerte for
• out of heart    forstemt, nedslået, i dårlig stand
• pour out one's heart    lette hjertet
• set one's heart on    få/have lyst til, forelske sig i
• shut one's heart to    afvise, lukke sig inde
• take heart    fatte mod
• the heart of    centrum
• to one's heart's content    af hjertens lyst
• wear one's heart on one's sleeve    bære sine følelser udenpå
• with all one's heart    af hele ens hjerte

Nederlands (Dutch)
hart, innerlijk, binnenste, gemoed, wil, karakter, emoties, (voor) liefde, verlangens, goedhartigheid, kern, boezem, hartklop, tikker, pit, hartspier/-klep na aan het hart

Français (French)
n. - (Anat) c¯ur, c¯ur (sentiments), sentiments profonds, nature, pitié, courage, centre, en pleine (jungle, campagne), fond (du problème), c¯ur (cartes), c¯ur (de laitue, d'artichaut)
v. tr. - encourager

idioms:

• at heart    à c¯ur
• broken heart    c¯ur brisé
• by heart    par c¯ur
• from the bottom of one's heart    du fond de son c¯ur
• from the heart    du c¯ur
• give heart    donner son c¯ur, encourager
• have a heart    avoir du c¯ur
• have a heart of gold    avoir un c¯ur d'or
• have one's heart in    mettre tout son c¯ur dans
• have one's heart in one's mouth    avoir le c¯ur sur la main
• have one's heart in the right place    avoir bon c¯ur
• have the heart to    avoir le c¯ur à
• heart and soul    corps et âme
• heart attack    infarctus, crise cardiaque
• heart failure    arrêt cardiaque
• heart of hearts    au plus profond
• heart's desire    désir le plus cher
• lose heart    perdre courage
• open one's heart    ouvrir son c¯ur
• out of heart    (GB) ne pas avoir le moral
• pour out one's heart    vider son sac, se confier
• put one's heart in    se donner corps et âme à
• set one's heart on    (vouloir) à tout prix qch/faire, compter sur
• shut one's heart to    fermer son c¯ur à
• take heart    prendre courage
• take something to heart    prendre qch à c¯ur
• the heart of    le c¯ur de/du
• to one's heart's content    à satiété, tout son soûl, (chanter) de tout son content
• wear one's heart on one's sleeve    laisser voir ses sentiments
• with all one's heart    avec/de tout son c¯ur

Deutsch (German)
n. - (Anat.)(Psych.) Herz, Kern(holz), Mittelpunkt, Zentrum, Herz (Spielkarte)
v. - ermutigen, ermuntern

idioms:

• at heart    im Grunde seines Herzens
• broken heart    gebrochenes Herz
• by heart    auswendig
• from the bottom of one's heart    aus tiefstem Herzen
• from the heart    von Herzen
• give heart    ermutigen
• have a heart    hab' Erbarmen!
• have a heart of gold    ein goldenes Herz haben
• have one's heart in    mit ganzem Herzen bei einer Sache sein, an jmdm./etw. interessiert sein
• have one's heart in one's mouth    Angst haben
• have one's heart in the right place    das Herz auf dem rechten Fleck haben
• have the heart to    etwas (nicht) übers Herz bringen
• heart and soul    mit ganzem Herzen
• heart attack    Herzanfall
• heart failure    Herzversagen
• heart of hearts    Inneres
• heart's desire    Herzenswunsch
• lose heart    den Mut verlieren
• open one's heart    sein Herz ausschütten
• out of heart    niedergedrückt
• pour out one's heart    sein Herz ausschütten
• put one's heart in    mit ganzem Herzen bei einer Sache sein
• set one's heart on    sein Herz an etwas hängen
• shut one's heart to    seine Herz verschließen
• take heart    Mut fassen
• take something to heart    sich etw. zu Herzen nehmen, beherzigen
• the heart of    der Kern der Sache
• to one's heart's content    nach Herzenslust
• wear one's heart on one's sleeve    das Herz auf der Zunge tragen
• with all one's heart    von ganzem Herzen

Ελληνική (Greek)
n. - καρδιά, (για παιγνιόχαρτα) κούπα, (μτφ.) ανθρωπιά, ευσπλαχνία, ψυχή, θάρρος, τόλμη

idioms:

• (not) have the heart to    δεν μου κάνει καρδιά να
• a heart of gold    χρυσή καρδιά
• at heart    κατά βάθος, βασικά
• break someone's heart    τσακίζω την καρδιά κάποιου
• broken heart    ραγισμένη καρδιά
• by heart    από στήθους, από μνήμης, απέξω
• close to one's heart    μέσα στην καρδιά μου, αγαπητός
• from the bottom of one's heart    από τα βάθη της καρδιάς μου
• from the heart    από καρδιάς, με το χέρι στην καρδιά
• give heart    ενθαρρύνω
• have a heart    δείξε έλεος!, λογικέψου
• have one's heart in one's mouth    είμαι με την ψυχή στο στόμα
• have one's heart in the right place    έχω ανθρωπιά (κι ας μην το δείχνω), είμαι λεβεντιά
• heart and soul    ολόψυχα, προθυμότατα
• heart attack    (παθολ.) καρδιακή προσβολή
• heart failure    (παθολ.) καρδιακή ανεπάρκεια, συγκοπή
• heart of hearts    τα (ε)σώψυχα, τα μύχια της καρδιάς
• heart's desire    όσο τραβάει η ψυχή σου
• lose heart    αποθαρρύνομαι
• open one's heart    ανοίγω την καρδιά μου, εκμυστηρεύομαι
• out of heart    (καθομ.) αποκαρδιωμένος
• pour out one's heart    ανοίγω την καρδιά μου
• set one's heart on    εποφθαλμιώ, ορέγομαι, λιμπίζομαι
• shut one's heart to    σφίγγω την καρδιά μου
• take heart    κάνω/παίρνω κουράγιο, αναθαρρεύω
• the heart of    η ουσία
• to one's heart's content    με την ψυχή μου
• wear one's heart on one's sleeve    χαρακτηρίζομαι από αυθορμητισμό, δεν κρύβω τα αισθήματά μου
• with all one's heart    με όλη μου την καρδιά

Italiano (Italian)
cuore, essenza

idioms:

• (not) have the heart to    (non) avere il coraggio di
• at heart    (avere) a cuore
• broken heart    cuore spezzato
• by heart    a memoria
• close/near to one's heart    caro a
• from the bottom of one's heart    dal profondo del cuore
• from the heart    dal profondo del cuore
• give heart    incoraggiare
• have a heart    aver pietà
• have one's heart in one's mouth    avere il cuore in gola
• have one's heart in the right place    essere sincero
• heart and soul    cuore ed anima
• heart attack    attacco cardiaco
• heart failure    collasso cardiaco
• heart of hearts    profondo del cuore
• lose heart    perdersi di coraggio
• open one's heart    confidarsi
• out of heart    infelice, depresso
• pour out one's heart    confidarsi
• set one's heart on    decidere fortemente di
• take heart    farsi coraggio
• the heart of    il nocciolo di
• to one's heart's content    a volontà
• wear one's heart on one's sleeve    parlare con il cuore in mano
• with all one's heart    con tutto il cuore

Português (Portuguese)
n. - coração (m), centro (m), o essencial (m), coragem (f), peito (m), copas (f pl)

idioms:

• (not) have the heart to    (não) ter a coragem de
• at heart    no fundo (fig.)
• broken heart    magoado (sentido)
• by heart    de memória
• close/near to one's heart    querido
• from the bottom of one's heart    do fundo do coração
• from the heart    de coração (sinceramente)
• give heart    apaixonar-se
• have a heart    ser bom
• have one's heart in one's mouth    ter o coração na mão
• have one's heart in the right place    ter boas intenções
• heart and soul    de corpo e alma (entusiasmado)
• heart attack    ataque (m) de coração (Med.)
• heart failure    colapso (m) cardíaco (Med.)
• heart of hearts    mais profundo sentimento
• lose heart    perder o ânimo
• open one's heart    abrir o coração (confessar)
• out of heart    de pura bondade
• pour out one's heart    confidenciar
• set one's heart on    ter idéia fixa em, ter saudades
• take heart    ter coragem
• the heart of    o coração de (o centro de)
• to one's heart's content    com alegria no coração
• wear one's heart on one's sleeve    comportar-se mostrando seus sentimentos
• with all one's heart    com todo coração

Русский (Russian)
сердце, душа, чувства, любовь, мужество, центральная часть, суть, интеллект, желудок

idioms:

• (not) have the heart to    не лежит сердце к
• at heart    в глубине души
• broken heart    разбитое сердце
• by heart    наизусть
• close/near to one's heart    близкий сердцу
• from the bottom of one's heart    из глубины души
• from the heart    от всего сердца
• give heart    подбодрить
• have a heart    быть милостивым, быть разумным
• have one's heart in one's mouth    струсить
• have one's heart in the right place    иметь добрые намерения
• heart and soul    всей душой
• heart attack    сердечный приступ
• heart failure    паралич сердца
• heart of hearts    зеница ока, самое дорогое
• lose heart    упасть духом
• open one's heart    раскрыть душу
• out of heart    уныло, несмело, в плачевном состоянии (о почве)
• pour out one's heart    изливать душу
• set one's heart on    стремиться к чему-либо
• take heart    собраться с духом
• the heart of    центр чего-л.
• to one's heart's content    вволю
• wear one's heart on one's sleeve    не уметь скрывать своих чувств
• with all one's heart    от всего сердца

Español (Spanish)
n. - corazón, fondo, fuero interno, lo esencial, centro
v. tr. - animar

idioms:

• at heart    en el fondo
• broken heart    corazón destrozado, lamentarse
• by heart    de memoria
• from the bottom of one's heart    de todo corazón
• from the heart    de todo corazón
• give heart    infundir ánimo
• have a heart    tenga piedad
• have a heart of gold    generoso por naturaleza, un corazón de oro
• have one's heart in    comprometerse o involucrarse en, tener el corazón puesto en algo
• have one's heart in one's mouth    tener el alma en un hilo, tener el corazón en la boca
• have one's heart in the right place    ser de buen corazón, ser una buena persona, ser sensato
• have the heart to    ser lo suficientemente insensible como para hacer algo, (no) tener corazón o valor para hacer algo
• heart and soul    con alma y vida
• heart attack    ataque cardíaco, infarto
• heart failure    colapso cardíaco
• heart of hearts    lo más recóndito del corazón
• heart's desire    deseo más ferviente, deseo más íntimo
• lose heart    descorazonarse, desalentarse
• open one's heart    abrirse, confiarse, descubrir el pecho
• out of heart    (GB) decaído, (GB) deprimido
• pour out one's heart    desahogarse
• put one's heart in    poner el alma en
• set one's heart on    poner el alma en, ansiar
• shut one's heart to    negarse a ver, a escuchar o a sentir, fingir no ver ni oír ni sentir
• take heart    cobrar ánimo
• take something to heart    tomar a pecho, tomar muy en serio
• the heart of    lo esencial, el grano
• to one's heart's content    a sus anchas, sin restricción, hasta quedarse satisfecho
• wear one's heart on one's sleeve    muy sensitivo o susceptible, con el corazón en un puño, contar abiertamente las intimidades
• with all one's heart    de todo corazón, con toda el alma

Svenska (Swedish)
n. - hjärta (äv. bildl.), kärna, hjärtekort, mod, ollon

中文（简体）(Chinese (Simplified))
心, 中心, 心脏, 把...放在中心

idioms:

• (not) have the heart to    (没有)有勇气做...
• a heart of gold    道德高尚的人
• at heart    内心里, 实际上, 本质上
• broken heart    心碎, 伤心, 失望
• by heart    熟记
• from the bottom of one's heart    衷心地
• from the heart    从心里, 真诚地, 深深地
• give heart    鼓励
• have a heart    发慈悲
• have one's heart in one's mouth    非常吃惊
• have one's heart in the right place    好心好意
• heart and soul    全心全意地
• heart attack    心脏病发作
• heart failure    心脏衰弱, 心力衰竭
• heart of hearts    率直的, 诚实的
• heart's desire    心里的愿望
• lose heart    失去勇气, 灰心失去勇气, 灰心
• open one's heart    吐露心中的隐秘
• out of heart    沮丧
• pour out one's heart    倾吐心事
• set one's heart on    渴望
• shut one's heart to    对...隐藏心里的事情
• take heart    振作
• the heart of    ...的中心部
• to one's heart's content    尽兴地
• wear one's heart on one's sleeve    十分坦率, 感情容易激动
• with all one's heart    全心全意地, 十分愿意地

中文（繁體）(Chinese (Traditional))
n. - 心, 中心, 心臟
v. tr. - 把...放在中心

idioms:

• (not) have the heart to    (沒有)有勇氣做...
• a heart of gold    道德高尚的人
• at heart    內心裡, 實際上, 本質上
• broken heart    心碎, 傷心, 失望
• by heart    熟記
• from the bottom of one's heart    衷心地
• from the heart    從心裡, 真誠地, 深深地
• give heart    鼓勵
• have a heart    發慈悲
• have one's heart in one's mouth    非常吃驚
• have one's heart in the right place    好心好意
• heart and soul    全心全意地
• heart attack    心臟病發作
• heart failure    心臟衰弱, 心力衰竭
• heart of hearts    率直的, 誠實的
• heart's desire    心裡的願望
• lose heart    失去勇氣, 灰心失去勇氣, 灰心
• open one's heart    吐露心中的隱秘
• out of heart    沮喪
• pour out one's heart    傾吐心事
• set one's heart on    渴望
• shut one's heart to    對...隱藏心裡的事情
• take heart    振作
• the heart of    ...的中心部
• to one's heart's content    盡興地
• wear one's heart on one's sleeve    十分坦率, 感情容易激動
• with all one's heart    全心全意地, 十分願意地

한국어 (Korean)
n. - 심장, 마음, 애정, 핵심
v. tr. - 마음에 새기다, 격려하다

idioms:

• a heart of gold    부드러운 마음
• at heart    실제로는, 마음에
• by heart    외어
• give heart    사모하다, 마음을 주다
• have a heart    인정이 많다, 이해하다
• have one's heart in one's mouth    깜짝 놀라다, 혼나다
• have one's heart in the right place    본성은 친절하다, 인정미가 있다, 악의가 없다
• take heart    마음을 다잡아 먹다, 용기를 내다
• the heart of    ~의 중심
• to one's heart's content    만족할 때까지, 충분히
• with all one's heart    진심으로, 마음속에서

日本語 (Japanese)
n. - 心臓, 胸部, 胸, 感情, 勇気, 気力, 熱意, 愛情, 中心, 核心, 真ん中
v. - 結球する, 心に銘記させる, 心材を詰める

idioms:

• (not) have the heart to    勇気がない, ～する気になれない
• a heart of gold    親切な心の人物
• at heart    心に, 心底は
• by heart    暗記して
• close/near to one's heart    なつかしい, 大事な
• from the heart    心から
• have a heart    正当である, 思いやりがある
• have one's heart in one's mouth    びっくり仰天する, ひどくおびえる
• have one's heart in the right place    根は親切気がある
• heart and soul    身も心も打ち込んで
• heart attack    心臓発作, 心臓麻痺
• heart failure    心臓麻痺, 心臓停止, 心不全
• heart massage    心臓マッサージ
• heart of hearts    傷ついた心
• out of heart    元気なく, やせて
• set one's heart on    望みをかける, 心を決める
• take heart    気を取り直す
• the heart of    中心部
• with all one's heart    心から, 喜んで

العربيه (Arabic)
‏(الاسم) قلب, فؤاد, الكوبه ورقه لعب تحمل صورة قلب, شخصيه الفرد بسماتها العاطفيه والعقليه, ذاكرة, طبيعه المرء العاطفيه والاخلاقيه, رأي, موقف, حنان, مزاج, حب, شجاعه, هم, رغبه ثابته, شخص مخلوق, لب, لباب‏

עברית (Hebrew)
n. - ‮לב, חזה, אמצע‬
v. tr. - ‮עודד, חיזק לב, המריץ, נסך אומץ ב-‬

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