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17-78 PDGF is encoded by a gene that can cause cancer when expressed inappropriately Why then do cancers not arise at wounds when PDGF is released from platelets?
Wiki User
∙ 12y ago
The on-demand, limited release of PDGF at a wound site
triggers cell division of neighboring cells for a limited
amount of time, until the PDGF is degraded. This is
different from the continuous release of PDGF from mutant
cells, where PDGF is made in an uncontrolled way at high
levels. Moreover, the mutant cells that make PDGF often
inappropriately express their own PDGF receptor, so
that they can stimulate their own proliferation, thereby
promoting the development of cancer
Wiki User
∙ 12y ago
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