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Target cells respond to hormones because they have specific receptors for the hormone on their cell membrane or inside the cell. These receptors enable the hormone to bind and initiate a cellular response. Other cells that do not have the specific receptors for that hormone are unaffected because they cannot bind to the hormone or activate the necessary signaling pathways.
The binding of a hormone to a receptor is the first step. Target cell activation by hormone-receptor interaction depends equally on 3 factors. First the blood levels of the hormone, second ,relative numbers of receptors for that hormone on or in the target cells and the third ,strength of the binding between the hormone cell and the receptors.
cortisol
They bond to receptor sites on their target cells to facilitate some reaction, depending on the hormone. For example, insulin is a protein hormone that bonds on receptor sites on muscle cells to allow the diffusion of glucose into the muscle cell. Without insulin, the cell membrane is impermeable to glucose, but the insulin bridge made when the hormone bonds with receptors on the muscle cell membrane allows for the glucose to pass through. This is called facilitated diffusion.
Target organs
where are receptors for non-steroid hormones located
receptors
target cells
Because they only activate target cells that have special receptors that only work when that specific hormone attaches to it.
The cells that react to a given hormone have special receptors for that hormone. When a hormone attaches to the receptor protein a mechanism for signaling is activated.
I think is down-regulation because a decrease in receptors will occur so less hormone can bind the cell.
The receptor changes shape and activates a chain reaction that leads to the cell changing its activities.
Target cells respond to hormones because they have specific receptors for the hormone on their cell membrane or inside the cell. These receptors enable the hormone to bind and initiate a cellular response. Other cells that do not have the specific receptors for that hormone are unaffected because they cannot bind to the hormone or activate the necessary signaling pathways.
plasma membrane
In your body, you have certain cells that can receive and process hormones released by your pituitary gland, hypothalamus and other endocrine glands. However, not all cells can receive all hormones. Target cells are cells that have receptors on them for a specific hormone. So a target cell may have a receptor for GH hormone, thus allowing GH to be absorbed by only the target cells with GH receptors.
The binding of a hormone to a receptor is the first step. Target cell activation by hormone-receptor interaction depends equally on 3 factors. First the blood levels of the hormone, second ,relative numbers of receptors for that hormone on or in the target cells and the third ,strength of the binding between the hormone cell and the receptors.
Only target cells have receptors inside cytoplazm (for steroid hormones) or on cell membrane (for protein hormones) that make the hormone active.