Kidney
Endothelial
aldosterone
Caffeine binds to aldosterone sites and thus causes an increase of aldosterone in the blood. This increase causes sodium re-absorption and potassium excretion. Sodium excites nerves as potassium relaxes them. This is why one looses their nerve with too much caffeine.
The target cells of aldosteron are in the distal convulated tubules. Aldosteron there spreads into the cells, makes complexes with the receptors of the nucleus and codes for genes that are responsible for the proteins (e.g. sodium permease) and ferments (citratsintase, carboanhidrase) that are important for the transfer of sodium ions.
Corticosteroids have some agonistic effects on Mineralocorticoids (aldosterone) thus dumping potassium and absorbing sodium.
The major target of aldosterone is the distal tubule of the kidney, where it stimulates exchange of sodium and potassium. Three primary physiologic effects of aldosterone result:Increased resorption of sodium: sodium loss in urine is decreased under aldosterone stimulation.Increased resorption of water, with consequent expansion of extracellular fluid volume. This is an osmotic effect directly related to increased resorption of sodium.Increased renal excretion of potassium.Knowing these effects should quickly suggest the cellular mechanism of action this hormone. Aldosterone stimulates transcription of the gene encoding the sodium-potassium ATPase, leading to increased numbers of "sodium pumps" in the basolateral membranes of tubular epithelial cells. Aldosterone also stimulates expression of a sodium channel which facilitates uptake of sodium from the tubular lumen.
Aldosterone is a hormone that is produced by the adrenal glands. It works primarily on kidney (renal) cells to help maintain the balance of fluids and electrolytes in our bodies. Its mainly works to control reabsorption of sodium and chloride and secretion of potassium and hydrogen. If aldosterone production is not functioning properly, there can be serious consequences to the heart, kidneys and electrolyte balance.
the effects are similar. Both hormones are Na+/H2O regulators in the kidneys, they just perform this function in different ways. ADH contros the H2O in our bodies and how much is released while aldosterone is in control of what is reabsorded.
increase urine composition and increace volume
Aldosterone will cause Na+ to be absorbed from a filtrate
Aldosterone promotes water retention and reduces urine volume
Aldosterone helps to indirectly regulate blood levels. A low sodium diet is a way to increase aldosterone in the body.