an increase in intracellular calcium ion levels
Heat exhaustion This is the loss of vital electrolytes which help contraction of muscles, these being potassium, sodium and magnesium.
All electrolytes are important to all muscles. In the cells there are sodium/potassium pumps that must be balanced. Some electrolytes are positive and some are negative. The balance (inside the cell vs. outside the cell) causes either contraction or relaxation.
The sodium potassium pump uses ATP to reach the stimulus and move muscle tissue (primarily skeletal muscle). The threshold stimulus must be reached in order to carry out the full signal.
sodium and potassium levels
Heat exhaustion This is the loss of vital electrolytes which help contraction of muscles, these being potassium, sodium and magnesium.
The acetylcholine diffuses across the synapse and binds to and activates nicotinic acetylcholine receptors on the motor end plate of the muscle cell. Activation of the nicotinic receptor opens its intrinsic sodium/potassium channel, causing sodium to rush in and potassium to trickle out.
There's more than one chemical that causes contraction. The neurotransmitter (usually acetylcholine) is released from the nerve and excites the muscle. There is a change in calcium, sodium and potassium ion concentrations. ATP is used. All of these work together to produce a muscle contraction.
Calcium is actually the main cation (positively charged ion) responsible for muscle contraction. Most people think it is Sodium or Potassium. Sodium is an anion (negatively charged ion) which controls your body's saturation (all the way down to the cellular level) and also aids in transporting minerals. What happens when you are dehydrated? Your muscles cramp up. Potassium is a cation which creates electricity. In muscle movement, sodium and potassium create a channel in which sodium rushes in and potassium rushes out causing the muscle fiber membrane to become more positively charged, triggering an action. This ultimately would not be possible without calcium, which starts the whole process. For more information check out the following link. References: http://en.wikipedia.org/wiki/Muscle_contraction AAOS Emergency Medical Technician Book
There are four electrolytes that are important to heart function, potassium, calcium, sodium and magnesium. Calcium is important in the actual contraction of the heart.
Two others are sodium and potassium.
Calcium
A loop diuretic affects the loops of Henle which regulate the uptake of sodium. The diuretic signal the kidney not to absorb calcium, potassium and magnesium and sodium The side effects are muscle weakness , cramps and palpitations.