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Metabolic acidosis

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Q: Blood gases show pH is 7.23 pCO2 is 38 pO2 is 77 HCO3- is 12 what is the patient suffering from?
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In what form is carbon dioxide carried through the blood?

Bicarbonate ion. HCO3(-)


In the h2co3 - hco3 buffering system the pka 6.10 as the normal pH of blood is 7.4 is there more h2co3 or na hco3?

ph=pka+log[A-]/HA A-= HCO3- HA= H2CO3 7.4=6.1+ log A-/HA 1.3=logA-/HA 10^1.3=A-/HA= 19.95 therefore the ratio of concetration is HCO3- is 19.95 to 1 H2CO3 or there is more HCO3


What are albumin blood buffers?

yes blood buffering does not have chemical in it because it is only composed of, H2CO3+H2O=H3O*+HCO3


What effect would an iv containing pure hco3 in an isotonic solution have on blood pH?

blood pH would increase


What effect would an IV containing pure HCO3- in an isotonic solution have on blood pH?

blood pH would increase


How is CO2 from the tissues converted into HCO3 in the blood?

CO2 combines with H2O in blood plasma to form H2CO3 (carbonic acid). Carbonic acid readily dissociates into HCO3 + H+ . The reaction between CO2 and water happens inside red blood cells, and the reaction is catalyzed by the enzyme carbonic anhydrase.


Is blood plasma a good buffer?

Yes. Main buffer is HCO3-. The pH of arterial blood plasma is 7.40.


What is HCO3-?

HCO3 is bicarbonate. Testing for HCO3 is usually done as part of arterial blood gas testing which determines whether the acid-base levels of the body are normal. Normal levels are pH 7.35-7.45, PaCO2 35-45 and HCO3 22-26. If the values for these measurements are outside the normal ranges, then the body has an acid-base imbalance. If the PaCO2 is off, the condition is a respiratory issue. if the HCO3 is outside the normal range, then it is a metabolic issue.


Why is the hematocrit value of venous blood slightly more than that of arterial blood?

It might be due to Hamburger's effect( chloride shift). In venous blood, RBC will take up CO2 and CO2 react with water to form carbonic acid ( H2CO3). This acid will then dissociate to form hydrogen ion ( H+) and bicarbonate ion (HCO3-). HCO3- will flow out from RBC and each efflux of HCO3- will be accompanied by influx of Cl-. In some circumstances, some HCO3- and Cl- remain in RBC or maybe the rat eof exchange of HCO3- and Cl- is not the same, and this create water flow into RBC, thus volume of RBC will increase (RBC swells) and hence it's hematocrit value too.


What is the difference between HCO3- and HCO3plus?

HCO3- is a anion (bicarbonate); HCO3+ don't exist.


What is the most important renal mechanism for regulating acid-base balance of the blood?

maintaining HCO3- balance


What is the primary form in which carbon dioxide is carried in blood?

As a bicarbonate ion in plasma