CO2 combines with H2O in blood plasma to form H2CO3 (carbonic acid). Carbonic acid readily dissociates into HCO3 + H+ .
The reaction between CO2 and water happens inside red blood cells, and the reaction is catalyzed by the enzyme carbonic anhydrase.
Carbon dioxide, produced by respiration, is carried in the blood in three ways: 1) As hydrogen carbonate (bicarbonate) ions (HCO3-) dissolved in the plasma (about 85%) 2) As carbamino-haemoglobin (carbon dioxide bound to haemoglobin) in the red blood cells (about 10%) 3) As carbon dioxide gas dissolved in the plasma (about 5%) See: http://www.elp.manchester.ac.uk/pub_projects/2001/MNQC7NDS/carbon_dioxide.htm http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/Blood.html http://www.chemsoc.org/networks/learnnet/cfb/transport.htm
Blood transports CO2 from tissue cells to the lungs in 3 forms:1) Dissolved in blood plasma (7 -- 10%)2) Chemically bound to Hb (around 20%), it forms a compound named carbaminohemoglobin. This reaction occurs rapidly and does not require an enzyme. CO2 binds directly to the amino acids of the Hb protein molecule.3) As bicarbonate ion (HCO3-) in plasma (about 70%): CO2 permeates (by simple diffusion) into the RBCs and combines with water. This reaction requires the presence of an enzyme called carbonic anhydrase. The result is carbonic acid (H2CO3), an unstable compound that quickly dissociates into H+ and HCO3-:CO2 + H2O + enzyme -------- H2CO3 -------- H+ + HCO3-The H+ formed, as well as CO2 itself, bind to hemoglobin molecules, triggering the called (Bohr effect). Thus, oxygen release is enhanced by CO2 loading. Because of the buffering effect of Hb, the liberated H+ causes little change in blood pH: arterial blood pH= 7.40; venous blood pH= 7.34.(Ahmed Urbizo, MDC STUDENT)
Red blood cells contain hemoglobin, which transports oxygen from the lungs to the body tissues and removes carbon dioxide from the body tissues. Hemoglobin binds to oxygen in the lungs and releases it in other tissues, while also picking up carbon dioxide to be exhaled from the body.
Carbon dioxide is transported in our blood to the lungs in one of three ways: 1. Dissolved in the plasma (10% of CO2 does this) 2. Attached to one of the amino groups on hemoglobin, to form a carbaminohemoglobin (HbCO2) (about 30% travel this way) 3. As bicarbonate in the plasma (about 60% go this way) I think your question relates most to the last option, so I'll just cover that. For CO2 to move to the lungs as bicarbonate, a few things have to happen at the tissues: -The CO2 enters the red blood cell -The red blood cell has carbonic anhydrase, an enzyme in it -The carbonic anhydrase allows the CO2 to join with water, which forms Carbonic acid. That formula is: CO2+H2O (in the presence of carbonic anhydrase) → H2CO3 -Carbonic acid is a weak acid. It breaks apart in the red blood cell to H+ and HCO3- (a hydrogen ion and bicarbonate) -the HCO3- will trade places with an ion of Chloride, which is outside the Red Blood Cell, floating around in the plasma. The Cl- and HCO3- are both negatively charged, so no charge change takes place. This is called the chloride shift. -So now the bicarbonate is in the plasma, and the H+ is in the RBC. The H+ will join with a molecule of Hemoglobin to form HHb or HHbO2 if an oxygen is attached. -When the RBC reaches the lungs, the bicarbonate shifts again with the chloride ion, and it rejoins again with the H+ to form H2CO3 carbonic acid -Under normal circumstances, in a breathing human, this carbonic acid will split into H2O and CO2, and the CO2 will be exhaled. Your question however is about a child who is holding her breath. The transport of ions moves in the same way, but once in the lungs, the CO2 will not be able to be exhaled. So her blood CO2 levels will increase, which will cause her blood to become more acidic. She will be able to hold her breath consciously for a short time only; if she passes out, the chemoreceptors located in the medulla oblongata and the pons will detect a decrease in pH, and will increase breathing rate to restore homeostasis.
Yes, carbon dioxide enters the blood stream in the body's tissues, where it is produced as a byproduct of metabolism. It is then carried in the blood back to the lungs, where it is exhaled from the body.
Carbon dioxide (CO2) is transported from the body's tissues to the alveoli primarily through three mechanisms: dissolved in plasma, bound to hemoglobin as carbamino compounds, and as bicarbonate ions (HCO3-) in the blood. In the tissues, CO2 diffuses into red blood cells, where it is converted to bicarbonate and transported in the plasma. Once the blood reaches the lungs, bicarbonate is converted back to CO2, which then diffuses into the alveoli. Finally, CO2 is expelled from the body during exhalation.
Bicarbonate ion (HCO3-) plays a crucial role in gas transport as the majority of carbon dioxide (CO2) produced in tissues is converted to bicarbonate for transportation in the blood. This conversion occurs in red blood cells through the action of the enzyme carbonic anhydrase. Bicarbonate is transported in the plasma to the lungs where it is converted back to CO2 for exhalation.
Carbon dioxide (CO2) in the blood is primarily transported in three forms: dissolved in plasma, bound to hemoglobin, and as bicarbonate ions (HCO3-). When CO2 enters the bloodstream from tissues, it diffuses into red blood cells, where it is converted to bicarbonate for easier transport. This conversion helps to regulate blood pH and facilitates the removal of CO2 from the body through the lungs during exhalation. Ultimately, CO2 is expelled from the body when we breathe out.
The blood changes from low CO2 to high CO2 in the tissues where oxygen is delivered and CO2 is produced as a byproduct of cellular metabolism.
Both oxygen and carbon dioxide diffuse from body tissues into the blood.
The behavior of CO2 in the blood is represented by the Henderson-Hasselbalch equation, which relates the pH of a solution to the concentration of bicarbonate and dissolved carbon dioxide. The equation is: pH = 6.1 + log([HCO3-] / 0.03 × PCO2), where [HCO3-] is the bicarbonate concentration and PCO2 is the partial pressure of carbon dioxide.
The reaction of CO2 with water to form bicarbonate (HCO3-) is a reversible reaction that occurs in the presence of carbonic anhydrase enzyme. The chemical equation for this reaction is: CO2 + H2O ↔ H2CO3 ↔ H+ + HCO3-.
Most carbon dioxide (CO2) in the bloodstream travels in the form of bicarbonate ions (HCO3-) after it reacts with water to form carbonic acid, which then dissociates. Approximately 70% of CO2 is transported this way. Additionally, about 20-25% is bound to hemoglobin as carbamino compounds, while a small percentage (around 5-7%) remains dissolved in plasma. This bicarbonate is then converted back to CO2 in the lungs for exhalation.
When CO2 dissolves in water, it forms carbonic acid (H2CO3) through the reaction CO2 + H2O -> H2CO3. This carbonic acid then dissociates into bicarbonate (HCO3-) and hydrogen ions (H+), leading to an increase in acidity (lower pH) in tissues. This acidity can disrupt normal cellular functions and enzyme activities.
It might be due to Hamburger's effect( chloride shift). In venous blood, RBC will take up CO2 and CO2 react with water to form carbonic acid ( H2CO3). This acid will then dissociate to form hydrogen ion ( H+) and bicarbonate ion (HCO3-). HCO3- will flow out from RBC and each efflux of HCO3- will be accompanied by influx of Cl-. In some circumstances, some HCO3- and Cl- remain in RBC or maybe the rat eof exchange of HCO3- and Cl- is not the same, and this create water flow into RBC, thus volume of RBC will increase (RBC swells) and hence it's hematocrit value too.
Hormones,O2,CO2,Digestive products,excretory products
The gases necessary (yes there are more than one) for respiration are oxygen and carbon dioxide. Oxygen plays the simpler role of the two. It is required by all cells of the body and can be passed along to the tissues via hemoglobin in red blood cells. Carbon Dioxide actually plays a very important role. It is the metabolic waste produced by cells, and it can be converted into bicarbonate ions by rbc to be transported in the blood, or bound to the globulin of hemoglobin and transported in this way. Its important role is its levels control respiration via peripheral and central chemoreceptors. To high CO2 levels and hyperventilation will reduce it or CO2 + H2O will be converted to bicarbonate ion (HCO3) and H ion. When CO2 is too low - hypoventilation will raise CO2 levels or the conversion of bicarbonate + H back to CO2 and water. It also plays and integral role in maintaining blood pH.