in the endoplasmic reticulum
At the heart of the immune response is the ability to distinguish between "self" and "non-self." Every cell in your body carries the same set of distinctive surface proteins that distinguish you as "self." Normally your immune cells do not attack your own body tissues, which all carry the same pattern of self-markers; rather, your immune system coexists peaceably with your other body cells in a state known as self-tolerance. This set of unique markers on human cells is called the major histocompatibility complex (MHC). There are two classes: MHC Class I proteins, which are on all cells, and MHC Class II proteins, which are only on certain specialized cells.
These proteins are called self markers. They tell the immune cells that they belong in the body and they should be attacked.Cell receptors (proteins) on the cell membrane mediate the inter cellular communications.
All cells produce antigens, or cell surface markers. The only question is whether the antigens are self antigens which means they belong in the body or they're foreign antigens which means they are an invading bacteria or virus (or a cancerous cell).
the red blood cells
This is protein called a self-marker. It sort of tells the immune cells that it belongs. If the immune cell doesn't read it right, it will attack and cause an autoimmune problem.
By recognizing self from non-self. Every cell in the body carries specific protein markers that are recognized by all immune cells so they do not attack self, at least when the system is operating well.
At the heart of the immune response is the ability to distinguish between "self" and "non-self." Every cell in your body carries the same set of distinctive surface proteins that distinguish you as "self." Normally your immune cells do not attack your own body tissues, which all carry the same pattern of self-markers; rather, your immune system coexists peaceably with your other body cells in a state known as self-tolerance. This set of unique markers on human cells is called the major histocompatibility complex (MHC). There are two classes: MHC Class I proteins, which are on all cells, and MHC Class II proteins, which are only on certain specialized cells.
These proteins are called self markers. They tell the immune cells that they belong in the body and they should be attacked.Cell receptors (proteins) on the cell membrane mediate the inter cellular communications.
At the heart of the immune response is the ability to distinguish between 'self' and 'non-self.'Every cell in your body carries the same set of distinctive surface proteins that distinguish you as 'self.' Normally your immune cells do not attack your own body tissues, which all carry the same pattern of self-markers.This set of unique markers on human cells is called the major histocompatibility complex (MHC). There are two classes: MHC Class I proteins, which are on all cells, and MHC Class II proteins, which are only on certain specialized cells.
All cells produce antigens, or cell surface markers. The only question is whether the antigens are self antigens which means they belong in the body or they're foreign antigens which means they are an invading bacteria or virus (or a cancerous cell).
a. attachment of MHC markers to self cells b. production of B and T lymphocytes c. phagocytosis of organisms foreign to the body d. oxygenation of the interstitial fluid e. destruction of red blood cells and recycling of their contents
the red blood cells
Self recognition immunity is when something goes into the body and it has been there before. The body automatically puts a marker specific to only that substance on it so that anytime it is in contact with the body it will recognize it. Non-recognized immunity is when a foreign substance enters the body. In this case the body has defense teams designed to attack and rid the body of the foreign substance. Sometimes the cells that are supposed to recognize the markers fail to and the body attacks it's own recognied substances. When this happens, this is the cause of many autoimmune diseases such as systemic lupus erythematosus, multiple sclerosis. OMG
A different cell surface protein serves to identify red blood cells as "self"; MHC 1 is not the only "self" marker. See this paper for more info.Role of CD47 as a Marker of Self on Red Blood CellsPer-Arne Oldenborg1,Alex Zheleznyak1,Yi-Fu Fang1,Carl F. Lagenaur2,Hattie D. Gresham3 andFrederik P. Lindberg1,*
The body's own cells
Antibodies are produced in response to antigens. An antigen can be anything foreign. You have markers on your cells that are self-markers. They say that you are you. You may be familare with the fact that you have a certain blood type. This is because of these markers on your red blood cells. They are called A, B, AB or O. As well as one called D (Rh- or Rh+). If you need a transfusion, you need a match or the antibodies that are already in the blood plasma will attack the transfused cells. When you need a new organ, your type must match as closely as possible to the donor or the organ will be rejected. If you have a splinter (an antigen), the body will fight it off and try to get rid of it. There are many examples like this.
Your body is partly made of protein. No protean - no body!.