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Both Keshan disease and Kashin-Beck disease are associated with a deficiency?
Wiki User
∙ 12y ago
Hello kids :),
Both of these diseases are due to Selenium deficiency. This deficiency comes from the lack of selenium in soil where your fruits and veggies are grown. Now a person can get either or. Keshan Disease is a combination of High Reative oxygen species + Coxsackie virus. This leads to Heart disease (fibrosis and lysis of cardiocytes). In Kashin-Beck disease think bones, necrosis of chondrocytes, dwarfism joint deformation--- also though defective RBC and fingernails.
Medical student at Ross university school of medicine
Wiki User
∙ 10y ago
Wiki User
∙ 12y agoselenium
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Deficiency is associated with what?
Keshan's disease
What is Selenium deficiency is associated with?
Keshan's disease
What research has been done on selenium deficiency?
many researchers who have investigated Keshan disease, a form of heart disease in children, believe that it is caused by selenium deficiency. The disease can be prevented but not cured with supplemental selenium
What are the symptoms of Keshan Disease?
General symptoms of Keshan's disease are:ArrhythmiaCardiac insufficiencyHeart enlargement - this can lead to heart failureLoss of heart tissueIf Keshan's disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency.It has also been suggested that Keshan's disease may be, at least partly due to infection by a virus (coxsackievirus B3 - CVB3/0), which would initially present with the typical viral infection symptoms such as:DiarrhoeaFeverLethargyMalaiseVomiting
What is the meaning of the name Keshan?
The name Keshan means versatile and able to learn easily. It is a name of African and Hebrew origin that is given to both girls and boys but mostly girls.
When were mistake children born?
October 7 1995 Keshan Bissoon
Was bob keshan a marine on Iwo Jima?
Bob Keshan "Captain Kangaroo" enlisted in the Marine Corps Reserve in 1945, but did not get out of the states when the war ended. This is an old urban legend attributed to actor Lee Marvin, who was wounded on Saipain.
What character did Bob Keshan play before Captain Kangaroo?
Clarabelle the Clown on the (Howdy Doody) program. he created the role, but ditched it. it was a non-speaking role.
What actors and actresses appeared in Running on Empty - 2012?
The cast of Running on Empty - 2012 includes: Peter Antonio Hernandez as Ice Pick Martin Gallo as Blade Keshan Jackson as Earl Travis Liston as Dean Jennifer Marie Gonzalez as Kathy Demien Myers as Brick Linda Saylor as Snipe
Which are the metals present in human body?
Elements in Animals and Humans Animals and humans have similar evolutionary backgrounds. Specific elements play critical roles in the structures of proteins and the activities of enzymes. The purpose of this page is to outline some of the uses of elements in the structure of animals and humans and to illustrate why these elements are essential in the body and for optimal health. * Calcium (Ca)Structure of bone and teeth. * Phosphorous (Ph)Structure of bone and teeth. Required for ATP, the energy carrier in animals. * Magnesium (Mg)Important in bone structure. Deficiency results in tetany (muscle spasms) and can lead to a calcium deficiency. * Sodium (Na)Major electrolyte of blood and extracellular fluid. Required for maintenance of pH and osmotic balance. * Potassium (K)Major electrolyte of blood and intracellular fluid. Required for maintenance of pH and osmotic balance. * Chlorine (Cl)Major electrolyte of blood and extracellular and intracellular fluid. Required for maintenance of pH and osmotic balance. * Sulfur (S)Element of the essential amino acids methionine and cysteine. Contained in the vitamins thiamin and biotin. As part of glutathione it is required for detoxification. Poor growth due to reduced protein synthesis and lower glutathione levels potentially increasing oxidative or xenobiotic damage are consequences of low sulfur and methionine and/or cysteine intake. * Iron (Fe)Contained in hemoglobin and myoglobin which are required for oxygen transport in the body. Part of the cytochrome p450 family of enzymes. Anemia is the primary consequence of iron deficiency. Excess iron levels can enlarge the liver, may provoke Diabetes and cardiac falurer. The genetic disease hemochromatosis results from excess iron absorption. Similar symptoms can be produced through excessive transfusions required for the treatment of other diseases. * Copper (Cu)Contained in enzymes of the ferroxidase (ceruloplasmin?) system which regulates iron transport and facilitates release from storage. A structural element in the enzymes tyrosinase, cytochrome c oxidase, ascorbic acid oxidase, amine oxidases, and the antioxidant enzyme copper zinc superoxide dismutase. A copper deficiency can result in anemia from reduced ferroxidase function. Excess copper levels cause liver malfunction and are associated with genetic disorder Wilson's Disease * Manganese (Mn)Major component of the mitochondrial antioxidant enzyme manganese superoxide dismutase. A manganese deficiency can lead to improper bone formation and reproductive disorders. An excess of manganese can lead to poor iron absorption. * Iodine (I)Required for production of thyroxine which plays an important role in metabolic rate. Deficient or excessive iodine intake can cause goiter (an enlarged thyroid gland). * Zinc (Zn)Important for reproductive function due to its use in FSH (follicle stimulating hormone) and LH (leutinizing hormone). Required for DNA binding of zinc finger proteins which regulate a variety of activities. A component of the enzymes alcohol dehydrogenase, lactic dehydrogenase carbonic anhydrase, ribonuclease, DNA Polymerase and the antioxidant copper zinc superoxide dismutase. An excess of zinc may cause anemia or reduced bone formation. * Selenium (Se)Contained in the antioxidant enzyme glutathione peroxidase and heme oxidase. Deficiency results in oxidative membrane damage with different effects in different species. Human deficiency causes cardiomyopathy (heart damage) and is known as Keshan's disease. * Fluorine (Fl)* Cobolt (Co)Contained in vitamin B12. An excess may cause cardiac failure. * Molybdenum (Mo)Contained in the enzyme xanthine oxidase. Required for the excretion of nitrogen in uric acid in birds. An excess can cause diarrhea and growth reduction. * Chromium (Cr)A cofactor in the regulation of sugar levels. Chromium deficiency may cause hyperglycemia (elevated blood sugar) and glucosuria (glucose in the urine). Rats have been shown to have improved growth on diets which contain other micro nutrients. These include: * Lead (Pb)* Nickel (Ni)* Silicon (Si)* Vanadium (Vn)These elements are all toxic at high levels. SOURCE: http://www.csua.berkeley.edu/~wuhsi/elements.htmlEducational Website
What is the importance of transition metals in the human body?
Animals and humans have similar evolutionary backgrounds. Specific elements play critical roles in the structures of proteins and the activities of enzymes. The purpose of this page is to outline some of the uses of elements in the structure of animals and humans and to illustrate why these elements are essential in the body and for optimal health. * Calcium (Ca)Structure of bone and teeth. * Phosphorous (Ph)Structure of bone and teeth. Required for ATP, the energy carrier in animals. * Magnesium (Mg)Important in bone structure. Deficiency results in tetany (muscle spasms) and can lead to a calcium deficiency. * Sodium (Na)Major electrolyte of blood and extracellular fluid. Required for maintenance of pH and osmotic balance. * Potassium (K)Major electrolyte of blood and intracellular fluid. Required for maintenance of pH and osmotic balance. * Chlorine (Cl)Major electrolyte of blood and extracellular and intracellular fluid. Required for maintenance of pH and osmotic balance. * Sulfur (S)Element of the essential amino acids methionine and cysteine. Contained in the vitamins thiamin and biotin. As part of glutathione it is required for detoxification. Poor growth due to reduced protein synthesis and lower glutathione levels potentially increasing oxidative or xenobiotic damage are consequences of low sulfur and methionine and/or cysteine intake. * Iron (Fe)Contained in hemoglobin and myoglobin which are required for oxygen transport in the body. Part of the cytochrome p450 family of enzymes. Anemia is the primary consequence of iron deficiency. Excess iron levels can enlarge the liver, may provoke diabetes and cardiac falurer. The genetic disease hemochromatosis results from excess iron absorption. Similar symptoms can be produced through excessive transfusions required for the treatment of other diseases. * Copper (Cu)Contained in enzymes of the ferroxidase (ceruloplasmin?) system which regulates iron transport and facilitates release from storage. A structural element in the enzymes tyrosinase, cytochrome c oxidase, ascorbic acid oxidase, amine oxidases, and the antioxidant enzyme copper zinc superoxide dismutase. A copper deficiency can result in anemia from reduced ferroxidase function. Excess copper levels cause liver malfunction and are associated with genetic disorder Wilson's Disease * Manganese (Mn)Major component of the mitochondrial antioxidant enzyme manganese superoxide dismutase. A manganese deficiency can lead to improper bone formation and reproductive disorders. An excess of manganese can lead to poor iron absorption. * Iodine (I)Required for production of thyroxine which plays an important role in metabolic rate. Deficient or excessive iodine intake can cause goiter (an enlarged thyroid gland). * Zinc (Zn)Important for reproductive function due to its use in FSH (follicle stimulating hormone) and LH (leutinizing hormone). Required for DNA binding of zinc finger proteins which regulate a variety of activities. A component of the enzymes alcohol dehydrogenase, lactic dehydrogenase carbonic anhydrase, ribonuclease, DNA Polymerase and the antioxidant copper zinc superoxide dismutase. An excess of zinc may cause anemia or reduced bone formation. * Selenium (Se)Contained in the antioxidant enzyme glutathione peroxidase and heme oxidase. Deficiency results in oxidative membrane damage with different effects in different species. Human deficiency causes cardiomyopathy (heart damage) and is known as Keshan's disease. * Fluorine (Fl)* Cobolt (Co)Contained in vitamin B12. An excess may cause cardiac failure. * Molybdenum (Mo)Contained in the enzyme xanthine oxidase. Required for the excretion of nitrogen in uric acid in birds. An excess can cause diarrhea and growth reduction. * Chromium (Cr)A cofactor in the regulation of sugar levels. Chromium deficiency may cause hyperglycemia (elevated blood sugar) and glucosuria (glucose in the urine). Rats have been shown to have improved growth on diets which contain other micro nutrients. These include: * Lead (Pb)* Nickel (Ni)* Silicon (Si)* Vanadium (Vn)These elements are all toxic at high levels. Source:http://www.csua.berkeley.edu/~wuhsi/elements.htmlEducational Website
Selenium in diet?
DefinitionSelenium is an essential trace mineral. Small amounts of selenium are good for your health.Alternative NamesDiet - seleniumFunctionSelenium has a variety of functions. It helps make special proteins, called antioxidant enzymes, which play a role in preventing cell damage. Some medical information suggests that selenium may help prevent certain cancers, but better studies are needed.There have also been mixed results regarding selenium's impact on cardiovascular disease.Selenium seems to stimulate antibodies after you receive a vaccination. It also may help protect the body from the poisonous effects of heavy metals and other harmful substances.Selenium may boost fertility, especially among men. The mineral has been shown to improve the production of sperm and sperm movement.Food SourcesPlant foods, such as vegetables, are the most common dietary sources of selenium. How much selenium is the vegetables you eat depends on how much of the mineral was in the soil where the plants grew.Fish, shellfish, red meat, grains, eggs, chicken, liver, and garlic are all good sources of selenium. Meats produced from animals that ate grains or plants found in selenium-rich soil have higher levels of selenium.Brewer's yeast, wheat germ, and enriched breads are also good sources of selenium.Side EffectsSelenium deficiency is rare in people in the United States. However, selenium deficiency may occur when a person is fed through a vein (IV line) for long periods of time.Keshan disease is caused by a deficiency of selenium. This leads to an abnormality of the heart muscle. Keshan disease caused many childhood deaths in China until the link to selenium was discovered and selenium supplements were provided.Two other diseases have been linked to selenium deficiency:Kashin-Beck disease, which results in joint and bone diseaseMyxedematous endemic cretinism, which results in mental retardationSevere gastrointestinal disorders may also affect the body's ability to absorb selenium.Too much selenium in the blood can cause a condition called selenosis. Selenosis can cause loss of hair, nail problems, nausea, irritability, fatigue, and mild nerve damage. However, selenium toxicity is rare in the United States.RecommendationsSelenium is often available in multivitamin and mineral supplements.The Food and Nutrition Board at the Institute of Medicine recommends the following dietary intake for selenium:Infants0 - 6 months: 15 micrograms per day (mcg/day)7 - 12 months: 20 mcg/dayChildren1 - 3 years: 20 mcg/day4 - 8 years: 30 mcg/day9 - 13 years: 40 mcg/dayAdolescents and AdultsMales age 14 and older: 55 mcg/dayFemales age 14 and older: 55 mcg/dayThe best way to get the daily requirement of essential vitamins is to eat a balanced diet that contains a variety of foods from the food guide pyramid.Specific recommendations depend on age, gender, and other factors (such as pregnancy). Women who are pregnant or producing breast milk (lactating) need higher amounts. Ask your health care provider which amount is best for you.ReferencesInstitute of Medicine, Food and Nutrition Board. Dietary Reference Intakes: Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academy Press, Washington, DC, 2000.Rakel D, ed. Integrative Medicine. 2nd ed. Philadelphia, Pa: Saunders Elsevier; 2007.Hamrick I, Counts SH. Vitamin and mineral supplements. Wellness and Prevention. December 2008:35(4);729-747.Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007.
