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Wellbutrin® (generic: bupropion) has not been implicated in worsening depression in clinical studies, but each person reacts differently, so there is a minor potential it could worsen depression in some individuals.

More often, when a person experiences worsening symptom or no improvement in symptoms, other factors are work. For example, the medication may not work for you; you may need a higher dose than you're currently taking; you may need to be patient, because it usually takes 3-6 weeks to see improvement; your doctor may need to supplement the medication with another class of antidepressants or mood stabilizers.

If you think you're becoming more depressed, talk to your doctor. He or she will know what to do next.

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Q: Can Wellbutrin cause worse depression in bipolar person?
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