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Technically no and this is why. Most English Mastiffs are calm and gentle, so a fight would probably never occure , but if it did happen they are almost balanced out, so it depends on the indevidual dogs strength and luck such as if the mastiff lifted its head up the pitbull could latch on to its neck or if the pitbull happened to fall lose its balance the mastiff could easily grab on to it's neck or stomach.

NEVER TRY DOING THIS!!!!!!!

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Q: Can a English mastiff kill a pitbull?
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