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Yes, easily, if it is large enough in caliber. For example, a 22 might penetrate the skull through the eye socket, but not have enough velocity after that to move further into the brain past the membranous covers of the brain to kill you. This could still severely damage you and your brain, but may not kill you. There is not much bone in the skull between the eye socket and the brain so a larger bullet could penetrate there much easier to do enough damage to kill the victim.

The covers between the brain and the skull that might stop small caliber ammunition from penetration of the brain are called the meninges. There are three different layers of the meninges that cover the spinal cord and brain and are called the pia, arachnoid and dura mater. They are each tough and fibrous. Bone of the skull is situated above these layers and below the periosteum and skin. The periosteum is another membrane that covers the outer surface of most bones through which the ammunition must also pass before getting to the meninges and brain. The very tough dura mater layer is located at the top of the other two meninges, just beneath the bone tissue and is the first line of defense after bone penetration.

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