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Yes.

A protein produced by multiple genes are cased by fusion genes.

Usually a protein is translated from a mRNA which is transcribed from a DNA. After transcription, RNA is rearranged by so-called RNA splicing in which some of short sequences are selected(Exon) or deleted(Intron). During the splicing two different genes can join together and it is called trans-splicing.

After trans-splicing, mRNA is translated into a protein, so the protein has two genes. Most cases these fusion genes are oncogenes which cause Cancerous diseases.

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Q: Can a single protein have multiple genes?
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