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I looked at the structure and it has two Carbonyl groups, C=O, so perhaps that oxygen can hydrogen bond with hydrogen on water, It also has three methyl groups, CH3, which are nonpolar, so I do not know how soluble caffeine is in water, but it surely is in coffee which is mostly water.

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11y ago
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6y ago

Yes - caffeine is an organic molecule with a bunch of covalent bonds (aka molecular bonds).

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Q: Can caffeine form Hydrogen bond
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