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You should not be taking Excedrin with Lortab (hydrocodone with acetaminophen), because they both contain acetaminophen (Tylenol). If you do, you need to exercise extreme caution.

Taking more than 4000mg of acetaminophen within a 24 hour period can cause liver damage, severe overdoses can cause liver failure.

You need to read both the labels on the Excedrin and the Lortab to know exactly how much acetaminophen is in each tablet. There are different types of Excedrin - some which have 250mg of acetaminophen per tablet, some which have 500mg. All hydrocodone formulations marketed under Lortab contain 500mg of acetaminophen per tablet. (Note: Vicodin, Norco, or the generic Hydrocodone/APAP - have other different formulations, some of which are higher than 500mg per pill).

If you have taken your Lortab and still need increased pain relief, other OTC medications you can consider are a straight aspirin medication (Like Bayer) or an ibuprofen (Advil, Motrin) or Naprosyn (Aleve).

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13y ago
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Wiki User

14y ago

Granted I am not a certified doctor, but as a sufferer of migraines all my life, I've tried every drug regime out there. I'm currently on Relpax and taking Excedrin migraine and Relpax together should be fine considering Excedrin migraine contains only caffeine and acetaminophen which should have no counteractions with eletriptan. But your best bet would be to ask your doctor because any of your medications could have a reaction.

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12y ago

It's not a good idea, as both have acetaminophen (Tylenol). Too much Tylenol can cause liver damage.

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Q: Can i take excedrin with lorazepam?
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