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While it is possible it may rarely help some people, Zoloft is not widely used to prevent migraine. Sertraline, or Zoloft, is an SSRI. Medications in the SSRI category are used to prevent migraines, however - Prozac is the most often used. Tricyclic antidepessants, which are older than SSRIs and also work with serotonin have proven more effective at preventing migraine. SNRIs, such as Cymbalta and Effexor, have also been proven effective.

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15y ago
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11y ago

All Migraine patients react differently to medicine including anti-depressants. What works for one will be ineffective on another. The answer to this question will be different for every patient. See your physician or headache specialist for appropriate diagnosis and treatment of Migraine and headache disorders.

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Q: Can sertraline be used to prevent migraine?
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