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Yes you can, do to chemical on them, such as starch, ect. Most likely you will become really itchy and break out in hives. Do wash before use. refer, i just woke up with hives from my new sheets.

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Yes, you can be sensitive to the "sizing" on new sheets. It is the starch and other chemicals used during manufacture and packaging. Wash your new sheets before using them.

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Q: Can someone have an allergic reaction to brand new bed sheets?
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