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Maybe once! ;) Serriously though the answer is a resounding "NO". The pressures of the .460 greatly exceed those recommended for the 45 Colt/410 barrel. I highly discourage the desire to test this. The results at the least will ruin a nice firearm and at most can kill you. Save your pennies and buy a gun built for it.

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Q: Can the 460 smith and Wesson cartridge be fired safely in a Thompson center 45 410 barrel?
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