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Can you give a description of an F8 or Category 8 tornado?

Updated: 12/20/2022
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∙ 8y ago
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There is no such thing as an F8 tornado or Category 8 hurricane in reality.

However, the Fujita scale does have theoretical categories up to F12, so that the scale connects the Beaufort wind scale and mach number.

We cannot get a size out of this supposed category as although strong tornadoes tend to be larger, size is not a factor in rating.

F8 wind estimates on this theoretical portion of the scale range from 446 mph to 513 mph.

However, the Fujita scale is based on damage, the wind speeds are only estimates for each damage level. Since F5 damage is total destruction, no tornado can be rated higher than F5.

As to hurricanes, any wind higher than 156 mph is category 5, no matter how high. So we cannot have a category 8.

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∙ 8y ago
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Is hemophilia a mutation?

Mutations in the F8 and F9 genes cause hemophilia. Changes in the F8 gene are responsible for hemophilia A, while mutations in the F9 gene cause hemophilia B. The F8 gene provides instructions for making a protein called coagulation factor VIII. A related protein, coagulation factor IX, is produced from the F9 gene. Coagulation factors are proteins that work together in the clotting process. After an injury, blood clots protect the body by sealing off damaged blood vessels and preventing further blood loss. Mutations in the F8 or F9 gene lead to the production of an abnormal version of coagulation factor VIII or coagulation factor IX. The altered protein cannot participate effectively in the blood clotting process and, in some cases, the protein does not work at all. A shortage of either protein prevents clots from forming properly in response to injury. These problems with blood clotting lead to excessive bleeding that can be difficult to control. Some mutations almost completely eliminate the activity of coagulation factor VIII or coagulation factor IX, resulting in severe hemophilia. Other mutations reduce but do not eliminate the activity of one of these proteins, which usually causes mild or moderate hemophilia. The other, rare form of this condition, acquired hemophilia, results when the body makes specialized proteins called autoantibodies that attack and disable coagulation factor VIII. The production of autoantibodies is sometimes associated with pregnancy, immune system disorders, cancer, or allergic reactions to certain drugs. In about half of cases, the cause of acquired hemophilia is unknown. Read more about the F8 and F9 genes. Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation must be present in both copies of the gene to cause the disorder. Males are affected by X-linked recessive disorders much more frequently than females. A striking characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. In X-linked recessive inheritance, a female with one altered copy of the gene in each cell is called a carrier. She can pass on the altered gene to her children, but usually does not experience signs and symptoms of the disorder. In about 10 percent of cases, however, females who carry one altered copy of the F8 or F9 gene will experience mild problems with bleeding. From: http://ghr.nlm.nih.gov/condition=hemophilia

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