Yes. These are two separate classes of medication that do not interact with each other, nor do they have similar effects that could amplify. In fact, Nyquil, being something you take for colds and flus, is formulated to be taken alongside other medications the cold/flu sufferer may take.
While it's always a good idea to check with your doc or pharmacist, I'd say you're safe on this as long as you follow the dosing instructions properly.
Nyquil contains alcohol. The mix of the two can increase the effects of alcohol significantly. In a worst case scenario, it can supress respiration to a dangerous level. Nyquil also contains acetaminiphen (Tylenol) which by itself can be dangerous if not taken correctly. So taking Nyquil with Adderall is not really a good idea. Basically, if you are sick and need something like Nyquil, you are probably trying to get some rest anyway, so don't take the Adderall when you are sick. In all situations, check with your doctor first. A quick call to the office should do it.
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