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No. You absolutely positively cannot take both NyQuil and Excedrin of any kind together. They both contain high levels of acetaminophen, which, if overdosed on, could hospitalize you. Excedrin also has aspirin. Whether or not you can take them over so many hours apart, however, is a question to ask.

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13y ago
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Q: Can you take NyQuil with excedrine migrane?
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