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Q: Can you take Zyrtec while taking Wellbutrin?
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I can only answer anecdotally. It appears that Wellbutrin & Zyrtec do react when used together. When my Wellbutrin got up'd to 300mg (I also take 100mg of Zoloft), the Zyrtec made me incredibly sleepy to the point where I felt drugged & would not have felt comfortable driving a car. Normally Zyrtec does not make me sleepy even when I was on 150mg of Wellbutrin with 100mg of Zoloft or on 200mg of Zoloft alone. I will keep taking the Zyrtec but will take it before bed now. If you need to take both, I strongly suggest trying when you have nothing to do & nowhere to go.


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No, wellbutrin needs to be taken in the way your doctor prescribed it to you. Most likely you were told to take it in the morning everyday. Wellbutrin needs to build up in your system and taking it everyday maintains an effective level.