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Well technically yes. There are many people who are prescribed both medications. The Seroquel is an anti-psychotic given to those who suffer from bi-polar/manic depression (although in smaller doses it is given as a sleep aid).

The codeine is a very mild version of the stronger opiates such as Hydrocodone, Oxycodone, and morphine. Funny enough, Codeine is a "pro-drug" because it actually converts to morphine in the blood stream. Of course the responsible thing for me to say is that you should only take the 2 together if prescribed...but let's get real...if you were prescribed them together you probably would not be asking the question to begin with LOL.

Medication reactions differ from person to person. For example, my husband takes 300mg XR Seroquel per day. If I were to take more than 25mg, I would be passed out for days! AND HE WEIGHS TWICE AS MUCH AS ME!! However in the same respect, I can take 3 Tylenol 4's w/Codeine and be pain free and slightly buzzed (which is wrong to say, but I am not going to lie to someone who wants a truthful answer). If my husband takes even ONE Tylenol 4 w/Codeine, he throws up all night.

Some people claim that Seroquel offers a hallucinogenic high accompanied by euphoria (similar to the feeling of being drunk). Others argue that when taken properly, Seroquel does not work instantly but rather kicks in over time (as with anti-depressants).

There is a moderate interaction between the 2 drugs...but it is only because they are both CNS depressants, and the pharmaceutical companies MUST advise the user about POSSIBLE respiratory depression. But in the same regard, you get the same warning about alcohol and Hydrocodone.

The best thing I can tell you is that if you are taking the drugs recreationally...take it slow, as Seroquel is a very powerful anti-psychotic. If you are prescribed both and are still worried...consult a pharmacist by calling a pharmacy in another town/citystate...in case you are worried about them "catching on" to abusive behavior.

PLEASE PLEASE do not listen to people on underground drug abuse forums...many of those people are beyond help and are probably taking ALOT more drugs than just these 2...and most likely in MUCH higher doses.

Be safe, consider the moderate interaction when dosing to avoid potential overdose (basically start with a low dose of each), and also check with a doctor or pharmacist (NOT an internet junkie that is beyond help).

WELL...there is your long answer, there is no harm in learning about what we put in our bodies...and now I will tell you what you really wanted to hear the whole time:

YES, they are safe together IN MODERATION (and legally, only if prescribed). If you have ANY other questions regarding medications, I will be glad to tell you what I know and what I have experienced. So if you feel like asking more questions or just want some 411...respond to this and I will check back!

Be well, take care of yourself, and feel better :)

PS: I am not condoning illegal drug use and I am also not judging those abusers on the forum...it is just the truth.

PPS: Please disregard my spelling errors, the spell check on the thing is really wonky! LOL. Take care :)

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12y ago
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Wiki User

12y ago

yes they are fine together

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