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Yes, a frog/toad can cause that type of reaction. My puppy was playing with a toad and a couple minutes later started pawing at her eyes. Now one is swollen. I live in Illinois so I'm pretty sure the thing is not poisonous. I just flushed her eye with cold water then applied a cold compress. It went down within the hour.

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Q: Could frogs cause swelling of lips and eyes on a dog?
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