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Yes it can. MSM caused rashes all over my body. I had been taking 1000mg for a year and upped it to 6,000, that's when I began to get rashes or hives.

Some say this is a sign of detox that will pass, but I'm skeptical about the detox theory since the vast majority of those who take it suffer zero side effects.

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Q: Could taking methylsulphonylmethane MSM cause a rash on your face?
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