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If you really meant to ask "What is the mass defect of oxygen-16," this is how you do it.

mass defect = # of protons x mass of one proton + # of neutrons x mass of one neutron - mass of the nucleus

The atomic number of oxygen-16 is 8, so there are 8 protons. The mass of one proton is approximately 1.0073 amu. The Atomic Mass of oxygen-16 is 16, so there are 8 neutrons in oxygen-16. (Atomic mass of 16 minus atomic number of 8 = # of neutrons in oxygen-16.) The mass of one neutron is approximately 1.0087 amu. The mass of the nucleus of oxygen is 16.

Now substitute the values into the "mass defect" equation:

mass defect = 8x1.0073+8x1.0087-16=approximately 0.128 amu.

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