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This will depend upon the specific microorganism you are asking about. Many common human pathogens, such as E. coli and Salmonella, do not grow at all below a water activity level of about 0.95. However, there are some bacteria that tolerate extremely dry conditions and can grow in places like the Sahara Desert, in the bottom of the Salt Lake in Utah and in other harsh conditions.

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Q: Do microorganism grow in dry conditions?
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