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I would not say all characters have AS on the show but Sheldon seems to be the most extreme (specific spot on couch, not very talkative unless he understands or has an interest, very specific into detail, interest in science and tends to be social in small groups).

The character Penny seems to be the exact opposite. Other characters like Howard and Leonard are too social to have Aspergers although Howard may show more AS traits than Leonard (stays at home, awkward around social events).

Besides Sheldon I would say that Raj, Sheldon's mother and Bernadette are closest to AS.

Raj (Has difficulty speaking to women such as Penny when asked directly, socially awkawrd but this may be the result that he is from India and its a different culture, ect)

Sheldon's Mother (very much like Sheldon but with an interest with Christianity)

Bernadette (similar to Sheldon)

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Q: Do the big bang theory characters all have aspergers syndrome?
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