Of course, meds effect everyone in different ways at different times. Some people absolutely need their Adderall everyday. I know some people who only need it along with anti-depressants, in the worst part of winter. Yet they don't need it at all when the weather is nice. Go figure.
However, if I stop taking my adderall for a length of time, I've been told to take a fraction of my full dosage at first and work back up to my usual dosage. Adderall is a stimulant so I guess - if you take high doses like I need - it could cause health problems to suddenly start taking high levels of it after a break.
The best thing to do, IMO, would be to call your doctor and ASK. If you are uncomfortable calling and asking your doctor a simple question like this, perhaps you should shop around for a physician you can be comfortable with.
Here is more from Wiki s Contributors:
Be careful with other meds, though. The SSRI types of drugs should be taken every day. These are most of the antidepressants and Strattera. The stimulants (ritalin, adderall, etc.) can be taken as needed. I took myself off of an antidepressant I was taking (gradually reduced the dosage over a couple of weeks) because I found it was interfering with my ability to become properly motivated by stressful situations.
It all depends on what functions you want to perform on a given day. If you have ADHD and you need to be alert, focused, and able to concentrate, on a given day, then you need to take it. If your activities on a given day will not require these abilities then you can get by with either a reduced dose or no dose. However, if you opt for "no dose," then your body will begin the Adderall withdrawal symptoms. The severity of these symptoms depends on how high a dose you were taking before you opted for "no dose" on a given day or weekend.
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