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Allegra (fexofenadine) should have no effect on a tuberculin skin test ("TB skin test"; "TST").

This is because the immune reaction responsible for a positive tuberculin skin test is mediated by specialized immune cells that move into the area of skin inoculated with the tuberculin agent. This type of immune reaction is known by doctors as a Type IV or "delayed-type" hypersensitivity (allergy) reaction. Another example of this type of hypersensitivity is the phenomenon of "contact dermatitis", an itchy, red, swollen reaction of skin to certain kinds of allergic stimuli (like poison ivy or nickel).

The type of hypersensitivity reaction that is controlled by Allegra and other antihistamines is a more rapid type that is caused by the release of histamine from a completely different group of immune cells (called "mast cells") in response to an allergic stimulus. The two types of hypersensitivity do not generally overlap, and so Allegra should have no effect on the delayed-type allergic reaction taken advantage of in the tuberculin skin test.

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Q: Does Allegra effect a TB test?
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Do you need to fast before a tuberculosis test?

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