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Levaquin is an antibiotic. Just tell the lab tech that you have recently taken it and they should be able to rule it out of the screening. If you do not inform them, it could potentially show as a false positive for opiates.

This is from Levaquins web site:

"Some quinolones, including levofloxacin, may produce false-positive urine screening results for opiates using commercially available immunoassay kits. Confirmation of positive opiate screens by more specific methods may be necessary."

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Q: Does Levaquin make a drug screen test-positive?
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