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Q: Does the body become more sensitive to insulin with aging?
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Why should you regulate blood sugar?

Your body regulates blood sugar. It is only if you have too much sugar (and carbohydrates break down into sugar) that the body can not keep up, does it become a problem. When you eat large amounts of sugar or carbohydrates, it requires the body to continuously produce high levels of insulin to keep that sugar level down. (Insulin's job is to push sugar out of the bloodstream into the cells where it is used for energy.) Eventually the cells in their body becomes insensitive to the effects of the insulin (insulin resistance). To handle this problem of insulin resistance their body begins to produce even higher levels of insulin. This continues until their pancreas reaches the maximum amount of insulin it can produce, and when the insulin resistance increases again, their blood sugar begins to rise out of control. The result is type 2 diabetes! Type 2 diabetes is actually an extreme case of insulin resistance. It is then that you have to regulate your blood sugar via diet, excerise and give you body some help to make the body's cells sensitive again to the insulin.


If you inject a diabetic shot by mistake would you be diabetic?

You do not become diabetic by injecting yourself with insulin; your body naturally produces insulin. You become diabetic when your pancreas stops working well (or stops working at all.) However, you could lapse into a coma and die if there is too much insulin in your body. Do NOT inject insulin into yourself or anyone else unless told by a doctor to do so.


Where does insulin in the body happen?

Insulin is produced in your pancreas.


What is endogenous insulin?

It is the insulin produced by your own body


What are the merits and demerits of using insulin injections instead of tablets in diabities?

This depends on many factors, especially whether you have diabetes type 1 versus type 2. Type 1: In this type, the cells in the body that make insulin (beta cells of the pancreas) are destroyed, so they cannot make insulin any more. For these patients, insulin is the ONLY option. Type 2: In this type, cells in the body become "insulin-resistant," meaning that they are not very efficient at using insulin any more. At first the body is still making insulin; since the body needs more than before the pancreas (mentioned above) keeps-up to make more and more insulin as the disease progresses. Eventually the cells in the pancreas get "tired" and go to the opposite extreme, making no insulin at all. In the early stages of Type 2 diabetes generally the oral medications are better (in addition to improving diet, exercise, etc.). They allow the body to improve its efficiency at using insulin, decreasing strain on the pancreas. As for the "merits": 1) they are more convenient. 2) they allow the body to continue to making its own insulin for as long as possible. 3) while both oral medications and insulin may cause "hypoglycemia" (low blood sugar, which can be very dangerous), this more often occurs with insulin. As far as "demerits," the main issue is that the oral medications don't work unless the body is still able to make enough of its own insulin. Sometimes the oral medications can cause upset stomach, but this usually resolves after a couple of weeks on the medication or after trying different doses/medications. Typically "metformin" has been the first drug tried in type 2 diabetics, though this can vary from patient-to-patient. It makes your liver and other insulin-requiring tissues in your body more sensitive to insulin, enabling them to more efficiently remove sugar from the blood; thus the pancreas doesn't have to work as hard. There are 3 other broad categories. One indirectly makes the body's tissues more sensitive to insulin, one "helps" the pancreas to secrete insulin, and another slows-down the rate at which sugars enter your body from the intestine. The advantage of insulin in Type 2 diabetes is that it works in those who are no longer able to make any of their own insulin. (And, like in Type 1, is the ONLY option for these patients.) Some may claim that it's better because it is just something the body makes naturally so it "can't hurt anything," not realizing that this is NOT an advantage in the case of insulin because it disrupts the body's regulating system. The body will lose its drive to make its own insulin (if it is still able to). So the biggest disadvantage of insulin is that once someone starts they'll likely become dependent on the outside insulin. It also is not as convenient to give injections versus swallowing a pill.


What happens to aging muscle cells?

When a human being is aging, their muscle cells also tend to age. Because of this, the muscle cells become weaker and the body is more prone to injury.


What happens to muscle cells in aging?

When a human being is aging, their muscle cells also tend to age. Because of this, the muscle cells become weaker and the body is more prone to injury.


What happens when a cell have too few insulin?

Insulin is a hormone that causes cells to absorb and store glucose. When the body fails to produce sufficient insulin, or the insulin is ineffective, the body cannot store glucose, and can become lethargic. Diabetes is the name for the condition where insulin is not functioning properly.


Does body weight increase from insulin injection?

No, body weight does not increase drom an insulin injection.


What else does METformin do besides lower glucose levels?

Metformin is thought to make the body more sensitive to insulin, so that there is less need to overproduce your own insulin. How it does this is not really known. Metformin also is thought to reduce gluconeogenesis, the process whereby your liver can synthesize glucose. It's principal mechanism is to make the body use existing insulin more efficiently, which does result in lower glucose levels for type II diabetics. However, Metformin is being studied as a Caloric Restriction mimetic in normal people. In this case, glucose levels would not necessarily be lowered, however insulin secretion will be lowered. Caloric restriction is the process of slowing aging through reduced energy intake. Some of the markers of this include reduced serum insulin levels. Since this is the purpose of Metformin, studies are underway to see if metformin slows aging. Research on nematodes and rats shows metformin does increase lifespan in these animals. Metformin can cause lactic acidosis in patients with poor renal function.


Why insulin is used?

Insulin is usually made in your body automatically; diabetes is when your body does not make enough insulin. So some people with diabetes have to take insulin to control their blood sugar.


What occurs in the body with type II diabetes?

In Type II diabetes, the pancreas may produce enough insulin, however, cells have become resistant to the insulin produced and it may not work as effectively