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no but penetrating the skull is not comfortable

~There are no pain sensors in most of the brain tissue itself, so your brain generally cannot feel pain; however, blood vessels and their supporting tissue that penetrate the brain, certain specific areas of the brain (e.g. the periaqueductal gray) and the surrounding tissues do have these pain sensors, which is why they do use anesthesia!

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Q: Does the brain experience pain during open-brain surgery?
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