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No. However the body has nicotinic receptors in nerve cells- places where nicotine binds to cause it's psychoactive effects. These receptors are probably also activated by substances created by the body which have a structure very similar to nicotine- it's not as though we'd evolve to all have a very special receptor created for the sole purpose of responding to a drug!

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Q: Does the human body naturally produce small amounts of nicotine?
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