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Q: Explain how an amino acid change causes sickle cell disease?
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What common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to what disease?

Sickle cell


What disease arises from an amino acid change in the protein hemoglobin?

Sickle Cell disease A disease that involves misshaped cells that can easily cause blood clots.


What type of mutation causes sickle cell anemia?

Sickle-cell disease (SCD), or sickle-cell anaemia or drepanocytosis, is an autosomal co-dominant genetic blood disorder characterized by red blood cells that assume an abnormal, rigid, sickle shape.


What are the causes of this disease and how is it transmitted sickle cell anemia?

it's caused by a mutation in the hemoglobin gene(a weird change that's basically in the red blood cell)disease is a group of genetic dis orders caused by sickle hemolobin(hgb s or hb s(


What are the causes of sickle-cell disease?

Sickle-cell Disease (SCD) is more common in those of African and Mediterranean decent; these people carry the sickle-cell trait; but not all who carry this gene develop the disease. This disease is caused by a genetic defect in an amino acid which shows in those who inherited this blood disease; SCD causes abnormal hemoglobin. This disease causes anemia which is caused by this mutation in the body's hemoglobin, B-globin chain. The abnormal gene causes irregular compounds in the red blood; hence the name Sickle-cell disease. The altered shape (crescent moon form) of the proteins inside of red blood cells causes them to clump and stick together leading to health issues.


What is the word for the genetic disorder that causes abnormal hemoglobin is known as?

sickle cell anemia. If you are only heterozygous for this disease it is simply called sickle trait.


Why is the sickle cell disease named that?

Because the condition causes the red blood cells to become sickle shaped rather than round.


What is sickle cell amenia?

Sickle Cell Anemia is an inherited blood disorder that causes the blood cells to change into a shape resembling a farmers sickle or a banana and makes blood flow difficult. There are many complications created by this disease. To learn more about the disease you could use this link: http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_Causes.html


Sickle cell disease is caused by a?

small change in the DNA of a single gene


How does disease affect the cell?

Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.


In sickle-cell disease variation in one gene causes red blood cells to bend or sickle. This means sickle cells?

Cannot carry normal levels of oxygen to cells :) *NovaNet*


In sickle cell disease variation in one gene causes red blood cell to bend or sickle. This means the sickle cells?

Cannot carry normal levels of oxygen to cells :) *NovaNet*