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What common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to what disease?
Wiki User
∙ 13y ago
Sickle cell
Wiki User
∙ 13y ago
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What is the word for the genetic disorder that causes abnormal hemoglobin is known as?
sickle cell anemia. If you are only heterozygous for this disease it is simply called sickle trait.
Why is genetic variation important to living things?
For one, without genetic variation, a species is more likely to face significant danger from disease. In humans there are some diseases that affect a few races more than others, but because of genetic variations, our species as a whole is more likely to adapt to new diseases and survive rather than if everybody had the same predisposition toward a disease.
What are cool disease names?
Elephantitis, which is hardly a cool disease. Mad Cow disease which can be maddening.
Does genetic drift increase or decrease genetic variation in populations and why?
It is important to understand that each individual has different genes. Genes can be lost if an individual dies without reproducing. To answer your question: There are two type of effects caused by Genetic Drift. The founder effect happens when a few species inhabit a new territory. If only those species reproduce then there are less genes in the gene pool and that leads to less variation. This can happen if storms sweep birds to a previously uninhabited island. The other effect is the bottleneck effect. This happens if a disease or poaching drastically reduces the number of individuals in a population. Since there are less individuals who can reproduce there are not as many genes that can be passed down.
Is cystic fibrosis a viral disease?
No. Cystic fibrosis is a genetic disease.
What are other names for sickle cell anemia?
Hemoglobin SS disease (Hb SS)
Is the mutation for hemoglobin S harmful or beneficial?
Hemoglobin S. This the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, a2bS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign.
What is the Life span for hemoglobin SC disease or hemoglobin S beta thalassemia?
4 months
What is an example of sickle cell?
A Sickle Cell is a type of Red Blood Cell (RBC) seen in the Sickle Cell Disease. This disease has an abnormal Hemoglobin molecule, termed Hemoglobin S. This is due to a point mutation in the Beta-Globin Gene on chromosome 11. The disease itself is homozygous and recessive so one can have the trait and not have the disease if one of the parents have it. The patients with this disease have lifelong hemolytic anemia and increased susceptibility to infections.As for how the cells came to be called Sickle Cells, one has to understand the molecular structure of the Globin (protein) portion of Hemoglobin. In this disease, a polar amino acid (Glutamate) is replaced by a non polar amino acid (Valine) in the Globin molecule, thus reducing its overall charge. This also causes a protrusion in the Hemoglobin surface that more or less fits a pocket like structure in another Hemoglobin molecule in the cell. During low oxygen tension, the hemoglobin molecules polymerize, or get attached to one another forming a network of mis-shaped, stiff and distorted cells. These cells are called Sickle Cells.
Is there an Autoimmune disease with low hemoglobin?
Graves' disease.....I am just adding to the graves disease answer... I have an auto immune disease called Aplastic Anemia. My immune system is attacking my bone marrow therefore making it hard to create my own blood... My hemoglobin was just at 5.2 so i chose to transfuse at that point.. At my last transfusion my hemoglobin was at 6.5,,, and so on... There is also an autoimmune disease called celaic disease where your body attacks your digestive system. This may sometimes cause internal bleeding making your hemoglobin drop from the loss of blood.
What protein is not normal in people with sickle-cell disease?
It is Hemoglobin
What protein is not normal in people with sickle- cell disease?
Hemoglobin
What is the normal Hemoglobin level in Sickle Cell disease?
8
In sickle cell disease the hemoglobin contains an incorrect?
heme
In which hereditary disease does abnormal hemoglobin differ from normal hemoglobin by only a single amino acid?
Sickle-cell anemia
How does disease affect the cell?
Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.
What is the disease where blood cells do not carry enough oxygen?
Anemia is a disease where the blood doesn't carry enough oxygen, due to either a lack of blood cells or hemoglobin, or damage to the blood cells or hemoglobin.
